2025-11-04 オランダ・デルフト工科大学(TUDelft)
<関連情報>
- https://www.tudelft.nl/en/2025/tnw/bacterial-spores-for-sustainable-smart-materials
- https://www.science.org/doi/10.1126/sciadv.adw8278
耐性とオンデマンド機能を備えた細菌培養生体材料 Bacterially grown living materials with resistant and on-demand functionality
Jeong-Joo Oh, Franka H. van der Linden, Koray Malcı, Ramon A. van der Valk, […] , and Marie-Eve Aubin-Tam
Science Advances Published:10 Oct 2025
DOI:https://doi.org/10.1126/sciadv.adw8278
Abstract
Inspired by naturally occurring biomaterials, autonomously grown engineered living materials (ELMs) feature cell-driven growth and programmable biological functions. However, the “livingness” of cells poses a short life span and low tolerance to harsh conditions, limiting the practical use of such materials. Here, we developed materials with programmable and dormant functionalities, grown from a mixture of Komagataeibacter rhaeticus and Bacillus endospores under engineered medium conditions. K. rhaeticus produces the bacterial cellulose (BC) matrix that integrates Bacillus spores within, whereas the confined spores keep dormant and are resistant to harsh conditions in the environment. Bacillus spores can germinate and confer desired functions to the materials. Modulating the binding affinity of spores to the BC matrix with genetic engineering can improve cell loading and therefore enhance the material functionality. These materials can serve as a versatile on-demand platform for applications as biosensors, biocatalytic materials, and in situ transformation of mechanically robust cellulose-based composites.
