2025-11-12 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/sons-of-mothers-with-type-1-diabetes-show-early-signs-of-vascular-dysfunction
- https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00527-0
母親の糖尿病は、代謝的に健康な子孫における性差のある早期発症の心血管機能障害を引き起こす Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
Allan Zhao ∙ Yuxia Wei ∙ Eftychia Kontidou ∙ … ∙ Sofia Carlsson ∙ Sergiu-Bogdan Catrina ∙ Qiaolin Deng
Cell Reports Medicine Published:November 11, 2025
DOI:https://doi.org/10.1016/j.xcrm.2025.102454
Graphical abstract
Highlights
- Maternal diabetes programs early-onset endothelial dysfunction in sons but not daughters
- Endothelial dysfunction in sons develops independent of metabolic disease
- Increased vascular oxidative stress and arginase 1 are identified as a mechanistic driver
- These findings highlight an underrecognized risk group for future preventive strategies
Summary
The incidence of cardiovascular disease (CVD) in young individuals is increasing. This alarming trend underscores the need to identify at-risk groups for preventive measures. Emerging evidence suggests that maternal diabetes increases the risk for metabolic diseases and early-onset CVDs in their offspring. However, the evidence is largely observational, limited by confounding factors, and lacks crucial mechanistic insight. Here, we combine experimental, epidemiological, and clinical approaches to disentangle the effects of maternal diabetes on offspring metabolism and endothelial function. In mice, we find that maternal hyperglycemia induces early-onset endothelial dysfunction specifically in male offspring, independent of metabolic disease. In humans, a case-control study and an epidemiological study confirm elevated risk of early-onset endothelial dysfunction and related CVDs in metabolically healthy sons of mothers with type 1 diabetes. Our findings identify an underrecognized risk group for early-onset CVDs and emphasize the importance of maternal conditions in shaping the cardiovascular health of future generations.
