2026-01-15 九州大学
図1 樹状突起スパインの高密度集積部位
<関連情報>
- https://www.kyushu-u.ac.jp/ja/researches/view/1390
- https://www.kyushu-u.ac.jp/f/64386/26_0115_01.pdf
- https://www.science.org/doi/10.1126/sciadv.adw8458
第5層ニューロンにおける樹状突起区画特異的スパイン形成は、思春期の皮質回路成熟の基礎となる Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence
Ryo Egashira, Meng-Tsen Ke, Nao Nakagawa-Tamagawa, Satoshi Fujimoto, […] , and Takeshi Imai
Science Advances Published:14 Jan 2026
DOI:https://doi.org/10.1126/sciadv.adw8458
Abstract
The development of cognitive functions continues into adolescence. However, it is not fully understood how cortical circuitry changes during adolescence. Here, we performed a comprehensive super-resolution mapping of dendritic spines in layer 5 extratelencepharic-projecting (L5 ET) neurons in the primary somatosensory cortex in mice. In adults, the dendritic spines are highly enriched in the middle compartment of the apical dendrites (spine density “hotspot”), where dendritic calcium spikes are generated. In early development, dendritic spines are evenly distributed. During adolescence, however, the spine density increases specifically in the middle compartment of the apical dendrites in an experience-dependent manner, while other dendritic compartments show a slight reduction. Furthermore, spine accumulation at the hotspot was specifically impaired in mouse models of schizophrenia, demonstrating a link between adolescent spine formation and neuropsychiatric disorders. Our finding suggests that the dendritic compartment-specific spine formation during adolescence shapes nonlinear dendritic integration in L5 ET neurons and supports the maturation of cognitive functions.
