2026-01-27 アメリカ国立衛生研究所(NIH)
<関連情報>
- https://www.nih.gov/news-events/news-releases/nih-funded-study-clearly-ties-risk-dementia-severe-cte
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71032
- https://medibio.tiisys.com/164807/
CTE神経病理学のみでも認知症や認知症状と関連している CTE neuropathology alone is associated with dementia and cognitive symptoms
Rachael M. Layden, Jenna R. Groh, Annalise E. Miner, Abigail Kidd, Sophia B. Nosek, Stephanie Gonzalez Gil, Bobak Abdolmohammadi, Steven Lenio, Christopher J. Nowinski, Yorghos Tripodis, …
Alzheimer’s & Dementia Published: 27 January 2026
DOI:https://doi.org/10.1002/alz.71032
Abstract
INTRODUCTION
This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.
METHODS
The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.
RESULTS
CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97–10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91–3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavioral scales.
DISCUSSION
CTE stage III/IV neuropathology was associated with dementia and cognitive symptoms: those with stage IV were 4.5 times more likely to have dementia than those without CTE. It is uncertain if low-stage CTE clinically manifests, and mood/behavioral symptoms likely have multifactorial causes and/or a fluctuating course.
Highlights
- Stage III and IV chronic traumatic encephalopathy (CTE) are independently associated with increased odds of having dementia.
- Higher CTE stage was associated with greater informant-reported cognitive symptoms.
- Stage I and II CTE were not associated with cognitive symptoms or dementia.
- CTE of any severity was not associated with informant-reported mood or behavioral symptoms.
