2026-02-19 スタンフォード大学
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<関連情報>
- https://news.stanford.edu/stories/2026/02/universal-respiratory-vaccine-nasal-spray
- https://med.stanford.edu/news/all-news/2026/02/universal-vaccine.html
- https://www.science.org/doi/10.1126/science.aea1260
マウスの粘膜ワクチン接種は多様な呼吸器系の脅威から保護する Mucosal vaccination in mice provides protection from diverse respiratory threats
Haibo Zhang, Katharine Floyd, Zhuoqing Fang, Filipe Araujo Hoffmann, […] , and Bali Pulendran
Science Published:19 Feb 2026
Abstract
Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus. In addition, the vaccine protected mice from other viruses (SARS-CoV-2, SARS, SCH014 coronavirus), bacteria (Acinetobacter baumannii), and allergens. Protection was mediated by persistent ovalbumin-specific CD4+ and CD8+ memory T cells that imprinted alveolar macrophages (AMs), enhancing antigen presentation and antiviral immunity. Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung. These results reveal a class of “universal vaccines” against diverse respiratory threats.
