2026-03-02 コペンハーゲン大学（UCPH）
＜関連情報＞
- https://news.ku.dk/all_news/2026/02/children-with-poor-oral-health-more-often-develop-cardiovascular-disease-as-adults/
- https://www.sciencedirect.com/science/article/pii/S0167527325011945
- https://link.springer.com/article/10.1007/s00592-024-02437-4
小児期の口腔衛生は、成人期の動脈硬化性心血管疾患の発症率と関連している Childhood oral health is associated with the incidence of atherosclerotic cardiovascular disease in adulthood
Nikoline Nygaard, Francesco D’Aiuto, Anne Kirstine Eriksen, Anja Olsen, Evelina Stankevic, Lars Ängquist, Torben Hansen, Daniel Belstrøm Merete Markvart
International Journal of Cardiology Available online: 1 January 2026
DOI:https://doi.org/10.1016/j.ijcard.2025.134151
Graphical abstract
Highlights
- First nationwide cohort study linking childhood oral health to adult atherosclerotic cardiovascular disease (ASCVD) incidence.
- Utilizing registry data from over 568,000 individuals spanning more than two decades.
- Poor oral health in childhood is associated with increased risk of adulthood ischemic heart disease, myocardial infarction, and ischemic stroke.
- Declining or persistently poor oral health trajectories across childhood is associated with higher ASCVD risk incidence.
Abstract
Background
While adult oral health has been consistently linked to cardiovascular disease, the long-term impact of childhood oral health remains underexplored. Thus, we investigated the association between dental caries and gingivitis in childhood and the incidence of atherosclerotic cardiovascular disease (ASCVD) in adulthood.
Methods
This nationwide Danish cohort study included 568,778 individuals born between 1963 and 1972, with oral health data from the National Child Odontology Registry (1972–1987) and ASCVD outcomes from the National Patient Register (1995–2018). Dental caries and gingivitis were categorized by severity and trajectory across childhood. Cox regression models stratified by sex, education level, and type 2 diabetes status were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CI) for incident ischemic heart disease, myocardial infarction, and ischemic stroke.
Results
Severe childhood dental caries was associated with increased ASCVD incidence in both males (HR 1.32; 95 % CI: 1.18–1.50) and females (HR 1.45; 95 % CI: 1.25–1.68). High gingivitis scores also predicted elevated ASCVD risk (males: HR 1.21; 95 % CI: 1.10–1.32; females: HR 1.31; 95 % CI: 1.14–1.50). Disease trajectories with moderate to severe level oral disease and oral health deterioration were significantly associated with higher ASCVD incidence.
Conclusion
Within the limitations of this study, poor childhood oral health, particularly persistent or worsening dental caries and gingivitis, is associated with an increased risk of ASCVD in adulthood. These findings highlight the potential of early oral health interventions in reducing long-term cardiovascular risk.
小児期の虫歯および歯肉炎と成人期の2型糖尿病との関連性に関する全国登録ベースのコホート研究 A nationwide registry-based cohort study of the association between childhood dental caries and gingivitis with type 2 diabetes in adulthood
Nikoline Nygaard,Anne Kirstine Eriksen,Lars Ängquist,Daniel Belstrøm,Evelina Stankevic,Torben Hansen,Anja Olsen & Merete Markvart
Acta Diabetologica Published:13 January 2025
DOI:https://doi.org/10.1007/s00592-024-02437-4
Abstract
Background
Evidence suggests a bidirectional relationship between oral health status and type 2 diabetes (T2D) in adults. Studies on associations between childhood oral health and T2D in adulthood are lacking.
Methods
This is a nationwide Danish registry-based cohort study of individuals born between 1963 and 1972, having at least one registration in the National Child Odontology Registry between 1972 and 1987 (n = 627,758). Follow-up lasted from 1995 to 2018. Main exposure variables were the highest achieved levels of dental caries and gingivitis between 1972 and 1987. The outcome was T2D diagnosis during follow-up. Data was analyzed using Cox-regression, stratified on sex, with age as the underlying timescale and highest achieved level of education between age 25–30 years as Cox-strata. Main analyses were conducted with and without age-restrictions (T2D diagnosis before/after age 40).
Results
Compared to lowest-level references, high levels of gingivitis associated with increased hazard ratios (HRs) of T2D in both males (HR [95% confidence interval]: 1.59 [1.47; 1.72]) and females (1.87 [1.68; 2.08]), as did severe dental caries (males: (1.15 [1.04; 1.27], in females: 1.19 [1.06; 1.35]). Below age 40, gingivitis associated with increased HRs in males (1.84 ([1.58; 2.15]) and females (1.94 [1.63; 2.30]). Above age 40, both exposures displayed higher HRs in males (high gingivitis: 1.52 [1.39; 1.66] vs. severe caries: 1.23 [1.09; 1.38]) and females (1.83 [1.59; 2.10] vs. 1.37 [1.17; 1.59]).
Conclusions
Data suggest an association between childhood dental caries and gingivitis with risk of receiving a T2D diagnosis in adulthood. However, results are affected by residual confounding warranting further studies.
