このうち、少なくともウイルスについては、他とは異なるものです(One of these things is not like the others, at least for viruses)

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インフルエンザ様疾患のより正確なモデル化は、アウトブレイクやパンデミックの治療に重要な利点をもたらす More accurate modeling of flu-like illness has important advantages for treating outbreaks, pandemics

2022-05-26 アメリカ・ロスアラモス国立研究所(LANL)

インフルエンザ様疾患の原因となる多くの呼吸器系ウイルスは、ウイルスやその治療法が劇的に異なるにもかかわらず、一般に医療専門家によって1つの総体として報告・追跡されています。米国だけでも、毎年5000万人近くが何らかのインフルエンザ様疾患(ILI)に感染している。このたび、ロスアラモス国立研究所とニューメキシコ大学の共同研究により、特定のウイルスをより詳細にモデル化することが、感染の早期発見と治療に不可欠であり、またパンデミックへの備えをより容易にすることが明らかになりました。

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インフルエンザ様疾患の原因ウイルスの見分け方 Distinguishing viruses responsible for influenza-like illness

Julie A.Spencer,Deborah P.Shutt,S. Kane Moser,HannahClegg,Helen J.Wearing,Harshini Mukundan,Carrie A.Manore
Journal of Theoretical Biology  Published:29 April 2022
DOI:https://doi.org/10.1016/j.jtbi.2022.111145

このうち、少なくともウイルスについては、他とは異なるものです(One of these things is not like the others, at least for viruses)

Abstract

The many respiratory viruses that cause influenza-like illness (ILI) are reported and tracked as one entity, defined by the CDC as a group of symptoms that include a fever of 100 degrees Fahrenheit, a cough, and/or a sore throat. In the United States alone, ILI impacts 9–49 million people every year. While tracking ILI as a single clinical syndrome is informative in many respects, the underlying viruses differ in parameters and outbreak properties. Most existing models treat either a single respiratory virus or ILI as a whole. However, there is a need for models capable of comparing several individual viruses that cause respiratory illness, including ILI. To address this need, here we present a flexible model and simulations of epidemics for influenza, RSV, rhinovirus, seasonal coronavirus, adenovirus, and SARS/MERS, parameterized by a systematic literature review and accompanied by a global sensitivity analysis. We find that for these biological causes of ILI, their parameter values, timing, prevalence, and proportional contributions differ substantially. These results demonstrate that distinguishing the viruses that cause ILI will be an important aspect of future work on diagnostics, mitigation, modeling, and preparation for future pandemics.

医療・健康
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