2022-08-03 ミシガン大学
1996年から2016年にかけて実施された「米国健康・退職者調査」の50歳以上の成人9,000人以上のインタビューデータを分析しました。1996年から2004年までの参加者の孤独の累積期間と、その後の2004年から2016年までの12年間の記憶機能の変化との関連を評価しました。
孤独と記憶老化の関連は、65歳以上の個人で最も強く、女性は男性よりも強く速い記憶力低下を示していた。
<関連情報>
- https://news.umich.edu/cumulative-loneliness-associated-with-accelerated-memory-aging-in-older-adults/
- https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12734
米国における50歳以上の成人における累積的な孤独感とその後の記憶機能および低下率(1996年～2016年)Cumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016
Xuexin Yu,Ashly C. Westrick,Lindsay C. Kobayashi
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association Published: 03 August 2022
DOI:https://doi.org/10.1002/alz.12734
Abstract
Introduction
The study objective was to investigate the association between loneliness duration and memory function over a 20-year period.
Methods
Data were from 9032 adults aged ≥50 in the Health and Retirement Study. Loneliness status (yes vs. no) was assessed biennially from 1996 to 2004 and its duration was categorized as never, 1 time point, 2 time points, and ≥3 time points. Episodic memory was assessed from 2004 to 2016 as a composite of immediate and delayed recall trials combined with proxy-reported memory. Mixed-effects linear regression models were fitted.
Results
A longer duration of loneliness was associated with lower memory scores (P < 0.001) and a faster rate of decline (P < 0.001). The association was stronger among adults aged ≥65 than those aged <65 (three-way interaction P = 0.013) and was stronger among women than men (three-way interaction P = 0.002).
Discussion
Cumulative loneliness may be a salient risk factor for accelerated memory aging, especially among women aged ≥65.
Highlight
- A longer duration of loneliness was associated with accelerated memory aging.
- The association was stronger among women than men and among older adults than the younger.
- Reducing loneliness in mid- to late life may help maintain memory function.
