時に有益、時に有害:酵素カメオの二重の役割(Sometimes beneficial, sometimes damaging: the double role of the enzyme chameau)

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2023-09-19 ミュンヘン大学(LMU)

◆研究によれば、ショウジョウバエにおいて、食物不足の期間に生存を支える役割を果たす「カメオ」という酵素が存在しますが、食物が豊富な場合には寿命を短縮する影響があります。カメオはタンパク質を修飾し、遺伝子調節に関与しています。過去の研究で、カメオの量を低下させると、栄養が豊富なショウジョウバエの寿命が延びることが分かっており、マウスでも同様の影響が報告されています。
◆この研究から、カメオは環境の変化に対処するために重要であり、寿命を延ばすよりも環境への適応が進化的に重要であるため、カメオがその不利益にもかかわらず保存されている可能性が示唆されています。

<関連情報>

ショウジョウバエの酢酸転移酵素カメオは、長寿を犠牲にして飢餓回復力を促進する。 The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity

Anuroop Venkateswaran Venkatasubramani,Toshiharu Ichinose,Mai Kanno,Ignasi Forne,Hiromu TanimotoS,hahaf Peleg,Axel Imhof
EMBO Reports  Published:19 September 2023
DOI:https://doi.org/10.15252/embr.202357023

Abstract

Proteins involved in cellular metabolism and molecular regulation can extend lifespan of various organisms in the laboratory. However, any improvement in aging would only provide an evolutionary benefit if the organisms were able to survive under non-ideal conditions. We have previously shown that Drosophila melanogaster carrying a loss-of-function allele of the acetyltransferase chameau (chm) has an increased healthy lifespan when fed ad libitum. Here, we show that loss of chm and reduction in its activity results in a substantial reduction in weight and a decrease in starvation resistance. This phenotype is caused by failure to properly regulate the genes and proteins required for energy storage and expenditure. The previously observed increase in survival time thus comes with the inability to prepare for and cope with nutrient stress. As the ability to survive in environments with restricted food availability is likely a stronger evolutionary driver than the ability to live a long life, chm is still present in the organism’s genome despite its apparent negative effect on lifespan.

Synopsis

時に有益、時に有害:酵素カメオの二重の役割(Sometimes beneficial, sometimes damaging: the double role of the enzyme chameau)

The fruit fly acetyltransferase chameau (chm) plays a role in controlling stress resilience. Our study provides an explanation for the chameau-mediated shortening of the lifespan. Chm mutant flies are in a state of constant caloric restriction, which is beneficial for extending their lifespan but detrimental if the animals face nutritional challenges.

  • The acetyltransferase chm plays a significant role in the physiology of fruit flies.
  • Mutant chm flies exhibit misregulation of genes and proteins involved in metabolic processes, including alterations in protein acetylation.
  • Fruit flies lacking chm have an extended lifespan but are more susceptible to starvation.
  • The primary importance of chm in addressing phenotypic defects is observed within the fat body, a specific tissue in fruit flies.
  • Tissue-specific expression of chm rescues the changes in physiology and the ability to respond to starvation.
生物化学工学
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