新規バイオマテリアルとマイクロサージェリーを組み合わせることで、より迅速な組織回復が可能になるかも(Combining novel biomaterial and microsurgery might enable faster tissue recovery)

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2024-03-05 ペンシルベニア州立大学(PennState)

ペンシルバニア州立大学の研究チームが、新しい生体材料と再建手術の微細外科手法を組み合わせ、ソフト組織の回復を改善する方法を開発しました。この手法は血管形成とパターン形成を加速し、ソフト組織の修復を助けることができることが示されました。研究者たちは7日間の実験で、この手法が誘導された血管ネットワークの形成を促進することを証明し、Small誌にその成果を発表しました。

<関連情報>

粒状ハイドロゲル足場と外科的マイクロパンクチャーを用いたパターン化血管形成の促進 Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture

Zaman Ataie, Summer Horchler, Arian Jaberi, Srinivas V. Koduru, Jessica C. El-Mallah, Mingjie Sun, Sina Kheirabadi, Alexander Kedzierski, Aneesh Risbud, Angelo Roncalli Alves E Silva …
Small  Published: 12 October 2023
DOI:https://doi.org/10.1002/smll.202307928

新規バイオマテリアルとマイクロサージェリーを組み合わせることで、より迅速な組織回復が可能になるかも(Combining novel biomaterial and microsurgery might enable faster tissue recovery)

Abstract

Bulk hydrogel scaffolds are common in reconstructive surgery. They allow for the staged repair of soft tissue loss by providing a base for revascularization. Unfortunately, they are limited by both slow and random vascularization, which may manifest as treatment failure or suboptimal repair. Rapidly inducing patterned vascularization within biomaterials has profound translational implications for current clinical treatment paradigms and the scaleup of regenerative engineering platforms. To address this long-standing challenge, a novel microsurgical approach and granular hydrogel scaffold (GHS) technology are co-developed to hasten and pattern microvascular network formation. In surgical micropuncture (MP), targeted recipient blood vessels are perforated using a microneedle to accelerate cell extravasation and angiogenic outgrowth. By combining MP with an adjacent GHS with precisely tailored void space architecture, microvascular pattern formation as assessed by density, diameter, length, and intercapillary distance is rapidly guided. This work opens new translational opportunities for microvascular engineering, advancing reconstructive surgery, and regenerative medicine.

医療・健康
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