2025-03-17 ペンシルベニア州立大学(PennState)
<関連情報>
- https://www.psu.edu/news/health-and-human-development/story/replacing-other-snacks-pecans-may-improve-cholesterol-diet
- https://www.sciencedirect.com/science/article/pii/S0002916525000577
スナックとしてピーカンを摂取することは、心代謝性疾患のリスクが高い成人において、通常の食事と比較して脂質/リポ蛋白質と食事の質を改善する:ランダム化比較試験 Consuming pecans as a snack improves lipids/lipoproteins and diet quality compared with usual diet in adults at increased risk of cardiometabolic diseases: a randomized controlled trial
Tricia L Hart, Penny M Kris-Etherton, Kristina S Petersen
The American Journal of Clinical Nutrition Available online: 27 January 2025
DOI:https://doi.org/10.1016/j.ajcnut.2025.01.024
Abstract
Background
The vascular and cardiometabolic effects of pecans are relatively understudied.
Objectives
The aim was to examine how substitution of usual snack foods with 57 g/d of pecans affects vascular health, risk factors for cardiometabolic diseases, and diet quality, compared with continuing usual intake in individuals at risk of cardiometabolic diseases.
Methods
A 12-wk single-blinded, parallel, randomized controlled trial was conducted. Adults with ≥1 criterion for metabolic syndrome who were free from cardiovascular disease and type 2 diabetes were included. Participants were provided with 57 g/d of pecans and instructed to replace the snacks usually consumed with the provided pecans. The control group was instructed to continue consuming their usual diet. Flow-mediated dilation (FMD),primary outcome, along with blood pressure, carotid-femoral pulse wave velocity (cf-PWV), lipids/lipoproteins, and glycemic control were measured at baseline and following the intervention. Participants completed 3 24-h recalls at 3 time points (baseline, week 6, and week 12) during the study (9 recalls in total). The Healthy Eating Index-2020 (HEI-2020) was calculated to assess diet quality.
Results
In total, 138 participants (mean ± SD; 46 ± 13 y, 29.8 ± 3.7 kg/m2) were randomly assigned (69 per group). No between-group differences in FMD, cf-PWV, or blood pressure were observed. Compared with the usual diet group, pecan intake reduced total cholesterol (-8.1 mg/dL; 95% confidence interval [CI]: -14.5, -1.7), LDL cholesterol (-7.2 mg/dL; 95% CI -12.3, -2.1), non-HDL-cholesterol (-9.5 mg/dL; 95% CI -15.3, -3.7), and triglycerides concentrations (-16.4 mg/dL; 95% CI -30.0, -2.9). Weight tended to increase in the pecan group compared with the usual diet group (0.7 kg; 95% CI -0.1, 1.4). The HEI-2020 increased by 9.4 points (95% CI 5.0, 13.7) in the pecan group compared with the usual diet group.
Conclusions
Replacing usual snacks with 57 g/d of pecans for 12-wk improves lipids/lipoproteins and diet quality but does not affect vascular health in adults at risk of cardiometabolic disease.
This trial was registered at clinicaltrials.gov as NCT05071807.
