2026-01-16 九州大学
*国立がん研究センター提供の年齢階級別罹患数(2014年)を元に算出
<関連情報>
- https://www.kyushu-u.ac.jp/ja/researches/view/1394
- https://www.kyushu-u.ac.jp/f/64444/26_0116_01.pdf
- https://link.springer.com/article/10.1007/s00535-025-02333-w
炎症性腸疾患患者における腸管外癌のリスク:日本における多施設共同後ろ向きコホート研究 Risk of extraintestinal cancer in patients with inflammatory bowel disease: a multicenter retrospective cohort study in Japan
Shin Fujioka,Junji Umeno,Teruyuki Takeda,Ken Kinjo,Takahide Tanaka,Nobuaki Nishimata,Shinichiro Yoshioka,Atsushi Iraha,Ryosuke Sakemi,Yoki Furuta,Nanae Tsuruoka,Shuji Kanmura,Kazuhiro Mizukami,Masayuki Hotokezaka,Yoshihiko Furuta,Fumihito Hirai,Tetsuro Ago & Motohiro Esakion behalf of the IBD-Quality Team
Journal of Gastroenterology Published:16 January 2026
DOI:https://doi.org/10.1007/s00535-025-02333-w
Abstract
Background
Studies investigating the incidence of extra-intestinal cancer (EIC) in Asian inflammatory bowel disease (IBD) patients are limited. The impact of thiopurines and anti-tumor necrosis factor (anti-TNF) antibodies on the development of EIC remains unclear.
Methods
In this multicenter retrospective cohort study, we analyzed data from 4604 IBD patients (1864 with Crohn’s disease [CD] and 2740 with ulcerative colitis [UC]) with a history of hospital visits between 2008 and 2020. The standardized incidence ratio (SIR) of EIC was calculated. To identify predictors of the presence of EIC, clinical characteristics and medication were evaluated. The cumulative probability of EIC was compared based on exposure to thiopurines and anti-TNF antibodies.
Results
EIC was identified in 65 CD patients and 97 UC patients. A higher incidence of leukemia was observed in CD patients (SIR 5.21). Gallbladder/bile duct cancer was more prevalent in UC patients (SIR 2.65), while gastric cancer was less common (SIR 0.46). Independent predictors of EIC in CD patients included female sex, age, disease duration, and complicated disease behavior, while in UC patients, predictors included age, primary sclerosing cholangitis, and current steroid use. Use of thiopurines in CD patients and anti-TNF antibodies in UC patients appeared protective against the presence of EIC. However, the duration of exposure to thiopurines and anti-TNF antibodies did not affect the development of EIC.
Conclusions
Japanese CD and UC patients seem to have a higher incidence of leukemia and gallbladder/bile duct cancer, respectively. Thiopurines and anti-TNF antibodies were not associated with an increased risk of EIC.
