UCIの研究者が、時間知覚における脳の線条体の繊毛の重要な役割を発見(UCI researchers discover crucial role of brain’s striatum cilia in time perception)


精神・神経疾患の新たな治療標的の可能性を示唆する成果 Results reveal possible new therapeutic targets for mental and neurological disorders

2022-11-30 カリフォルニア大学校アーバイン校(UCI)



線条体の繊毛はタイミングに依存した機能を媒介する Cilia in the Striatum Mediate Timing-Dependent Functions

Wedad Alhassen,Sammy Alhassen,Jiaqi Chen,Roudabeh Vakil Monfared & Amal Alachkar
Molecular Neurobiology  Published:02 November 2022


Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the significance of cilia, once considered vestigial organelles, in the higher-order brain functions is unknown. Cilia act as a hub that senses and transduces environmental sensory stimuli to generate an appropriate cellular response. Similarly, the striatum, a brain structure enriched in cilia, functions as a hub that receives and integrates various types of environmental information to drive appropriate motor response. To understand cilia’s role in the striatum functions, we used loxP/Cre technology to ablate cilia from the dorsal striatum of male mice and monitored the behavioral consequences. Our results revealed an essential role for striatal cilia in the acquisition and brief storage of information, including learning new motor skills, but not in long-term consolidation of information or maintaining habitual/learned motor skills. A fundamental aspect of all disrupted functions was the “time perception/judgment deficit.” Furthermore, the observed behavioral deficits form a cluster pertaining to clinical manifestations overlapping across psychiatric disorders that involve the striatum functions and are known to exhibit timing deficits. Thus, striatal cilia may act as a calibrator of the timing functions of the basal ganglia-cortical circuit by maintaining proper timing perception. Our findings suggest that dysfunctional cilia may contribute to the pathophysiology of neuro-psychiatric disorders, as related to deficits in timing perception.