JILAの周波数コム式飲酒検知器、COVID-19を優れた精度で検出(JILA’s Frequency Comb Breathalyzer Detects COVID-19 with Excellent Accuracy)


2023-04-06 米国国立標準技術研究所(NIST)



超高感度広帯域レーザー分光法による呼気分析でSARS-CoV-2感染症を発見 Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection

Qizhong Liang, Ya-Chu Chan, Jutta Toscano, Kristen K Bjorkman, Leslie A Leinwand, Roy Parker, Eva S Nozik, David J Nesbitt and Jun Ye
Journal of Breath Research  Published: 5 April 2023

Figure 1.


Rapid testing is essential to fighting pandemics such as coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exhaled human breath contains multiple volatile molecules providing powerful potential for non-invasive diagnosis of diverse medical conditions. We investigated breath detection of SARS-CoV-2 infection using cavity-enhanced direct frequency comb spectroscopy (CE-DFCS), a state-of-the-art laser spectroscopic technique capable of a real-time massive collection of broadband molecular absorption features at ro-vibrational quantum state resolution and at parts-per-trillion volume detection sensitivity. Using a total of 170 individual breath samples (83 positive and 87 negative with SARS-CoV-2 based on reverse transcription polymerase chain reaction tests), we report excellent discrimination capability for SARS-CoV-2 infection with an area under the receiver-operating-characteristics curve of 0.849(4). Our results support the development of CE-DFCS as an alternative, rapid, non-invasive test for COVID-19 and highlight its remarkable potential for optical diagnoses of diverse biological conditions and disease states.