2023-07-10 ワシントン大学セントルイス校
◆この低コストの装置は、医療施設や学校などで使用され、CoV-2だけでなく他の呼吸器ウイルスも監視するのに役立つ可能性があります。研究結果はNature Communications誌に掲載されました。この技術は、部屋の安全性をリアルタイムで把握し、適切な対策を取ることができる可能性を示唆しています。
<関連情報>
- https://source.wustl.edu/2023/07/air-monitor-can-detect-covid-19-virus-variants-in-about-5-minutes/
- https://www.nature.com/articles/s41467-023-39419-z
SARS-CoV-2エアロゾルのリアルタイム環境監視 Real-time environmental surveillance of SARS-CoV-2 aerosols
Joseph V. Puthussery,Dishit P. Ghumra,Kevin R. McBrearty,Brookelyn M. Doherty,Benjamin J. Sumlin,Amirhossein Sarabandi,Anushka Garg Mandal,Nishit J. Shetty,Woodrow D. Gardiner,Jordan P. Magrecki,David L. Brody,Thomas J. Esparza,Traci L. Bricker,Adrianus C. M. Boon,Carla M. Yuede,John R. Cirrito & Rajan K. Chakrabarty
Nature Communications Published:10 July 2023
DOI:https://doi.org/10.1038/s41467-023-39419-z
Abstract
Real-time surveillance of airborne SARS-CoV-2 virus is a technological gap that has eluded the scientific community since the beginning of the COVID-19 pandemic. Offline air sampling techniques for SARS-CoV-2 detection suffer from longer turnaround times and require skilled labor. Here, we present a proof-of-concept pathogen Air Quality (pAQ) monitor for real-time (5 min time resolution) direct detection of SARS-CoV-2 aerosols. The system synergistically integrates a high flow (~1000 lpm) wet cyclone air sampler and a nanobody-based ultrasensitive micro-immunoelectrode biosensor. The wet cyclone showed comparable or better virus sampling performance than commercially available samplers. Laboratory experiments demonstrate a device sensitivity of 77–83% and a limit of detection of 7-35 viral RNA copies/m3 of air. Our pAQ monitor is suited for point-of-need surveillance of SARS-CoV-2 variants in indoor environments and can be adapted for multiplexed detection of other respiratory pathogens of interest. Widespread adoption of such technology could assist public health officials with implementing rapid disease control measures.
