小児期の大気汚染曝露が早期死亡につながる(Childhood air pollution exposure link to early death)

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2023-09-19 エディンバラ大学

◆スコットランドで1936年に生まれた3,000人以上の人々を対象に行われた研究によれば、幼少期に高濃度の大気汚染にさらされた人々は、低濃度にさらされた人々に比べて、65歳から86歳までの間に死亡するリスクが高まりました。特に女性では肺がんのリスクも増加しました。
◆この研究は、大気汚染と健康の関連性を75年間にわたって明らかにし、認知能力の低下も影響の一部であることを示唆しています。空気品質の悪化が生涯にわたる影響を持つことが明らかになり、大気汚染削減の重要性が強調されています。

<関連情報>

早期のPM2.5曝露、小児期の認知能力、11~86歳の死亡率:スコットランドの記録連関ライフコース研究 Early life PM2.5 exposure, childhood cognitive ability and mortality between age 11 and 86: A record-linkage life-course study from scotland

Gergő Baranyi, Lee Williamson, Zhiqiang Feng, Sam Tomlinson, Massimo Vieno, Chris Dibben
Environmental Research  Available online :31 August 2023
DOI:https://doi.org/10.1016/j.envres.2023.117021

小児期の大気汚染曝露が早期死亡につながる(Childhood air pollution exposure link to early death)

Highlights

•We explored PM2.5 at age 3 and mortality between age 11 and 86 in a Scottish cohort.
•PM2.5 increased the risk of all-cause mortality, especially between the age of 65 and 86.
•Childhood cognitive ability mediated 25% of the total association.
•Associations were prominent for (lung) cancer mortality, especially among females.
•Air pollution in early life may affect health and longevity across the life course.

Abstract

Background
Living in areas with high air pollution concentrations is associated with all-cause and cause-specific mortality. Exposure in sensitive developmental periods might be long-lasting but studies with very long follow-up are rare, and mediating pathways between early life exposure and life-course mortality are not fully understood.

Methods
Data were drawn from the Scottish Longitudinal Study Birth Cohort of 1936, a representative record-linkage study comprising 5% of the Scottish population born in 1936. Participants had valid age 11 cognitive ability test scores along with linked mortality data until age 86. Fine particle (PM2.5) concentrations estimated with the EMEP4UK atmospheric chemistry transport model were linked to participants’ residential address derived from the National Identity Register in 1939 (age 3). Confounder-adjusted Cox regression estimated associations between PM2.5 and mortality; regression-based causal mediation analysis explored mediation through childhood cognitive ability.

Results
The final sample consisted of 2734 individuals with 1608 deaths registered during the 1,833,517 person-months at risk follow-up time. Higher early life PM2.5 exposure increased the risk of all-cause mortality (HR = 1.03, 95% CI: 1.01–1.04 per 10 μg m-3 increment), associations were stronger for mortality between age 65 and 86. PM2.5 increased the risk of cancer-related mortality (HR = 1.05, 95% CI: 1.02–1.08), especially for lung cancer among females (HR = 1.11, 95% CI: 1.02–1.21), but not for cardiovascular and respiratory diseases. Higher PM2.5 in early life (≥50 μg m-3) was associated with lower childhood cognitive ability, which, in turn, increased the risk of all-cause mortality and mediated 25% of the total associations.

Conclusions
In our life-course study with 75-year of continuous mortality records, we found that exposure to air pollution in early life was associated with higher mortality in late adulthood, and that childhood cognitive ability partly mediated this relationship. Findings suggest that past air pollution concentrations will likely impact health and longevity for decades to come.

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