BNPペプチドが湿疹の原因であることが判明(BNP Peptide a Culprit in Eczema)


2023-10-19 ノースカロライナ州立大学(NCState)

itchy skin
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Brain Natriuretic Peptide Exerts Inflammation and Peripheral Itch in a Mouse Model of Atopic Dermatitis

Joshua J. Wheeler,Nidha Williams,Junho Yu,Santosh K. Mishra
Journal of Investigative Dermatology  Published:October 11, 2023

Atopic dermatitis (AD) is a globally prevalent disease that affects both children and adults, and the incidence of AD is increasing worldwide (Bylund et al., 2020). AD is characterized by dry, inflamed, and itchy skin, but the etiology behind neuroinflammation and itch related to AD skin is only beginning to be understood. The brain natriuretic peptide (BNP), a byproduct of the Nppb gene, is expressed in primary afferent neurons which are known to be responsible for central itch (Mishra and Hoon, 2013), (Pitake et al., 2018,Meng et al., 2018) (Mishra et al., 2020) (Usoskin et al., 2015). Periostin, an extracellular matrix protein is highly expressed in chronic allergic/inflammatory skin diseases and most recently implicated in itch (Hashimoto et al., 2021). However, the precise role of BNP in peripheral skin-derived inflammation and itch remains unclear. Here we sought to investigate the possible mechanistic relationship between BNP and the extracellular matrix protein periostin in neurogenic inflammation and itch using BNP knockout (KO) mice. The current study aimed 1) to examine whether BNP causes peripheral skin inflammation and itch; and 2) to determine if BNP-induced release of periostin (and perhaps additional cytokines) is related to inflammation and itch.