2024-01-17 カリフォルニア大学サンディエゴ校(UCSD)
<関連情報>
- https://today.ucsd.edu/story/transforming-clinical-recording-of-deep-brain-activity-with-a-new-take-on-sensor-manufacturing
- https://www.nature.com/articles/s41467-023-43727-9
柔軟でスケーラブル、高チャンネル数のヒト脳内記録用ステレオ電極 Flexible, scalable, high channel count stereo-electrode for recording in the human brain
Keundong Lee,Angelique C. Paulk,Yun Goo Ro,Daniel R. Cleary,Karen J. Tonsfeldt,Yoav Kfir,John S. Pezaris,Youngbin Tchoe,Jihwan Lee,Andrew M. Bourhis,Ritwik Vatsyayan,Joel R. Martin,Samantha M. Russman,Jimmy C. Yang,Amy Baohan,R. Mark Richardson,Ziv M. Williams,Shelley I. Fried,U. Hoi Sang,Ahmed M. Raslan,Sharona Ben-Haim,Eric Halgren,Sydney S. Cash & Shadi. A. Dayeh
Nature Communications Published:17 January 2024
DOI:https://doi.org/10.1038/s41467-023-43727-9
Abstract
Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.
◆これにより、治療抵抗性てんかんなどの患者を30日間にわたりワイヤレスモニタリングする技術が初めて実現し、将来的には他の障害にも応用できる可能性がある。プローブは臨床用材料から作られ、非常に小さなサイズであるため、脳に極めて近い位置に配置でき、特定の領域での高解像度検知が可能。革新的な製造手法により、プローブごとのチャネル数を数千にまで拡大でき、医師の脳信号の理解と治療能力が向上する。