2024-02-16 エディンバラ大学
<関連情報>
- https://www.ed.ac.uk/news/2024/trial-shows-wonder-material-can-be-developed-safel
- https://www.nature.com/articles/s41565-023-01572-3
酸化グラフェンナノシートの吸入をヒトで初めて制御し、急性心肺反応を研究 First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Jack P. M. Andrews,Shruti S. Joshi,Evangelos Tzolos,Maaz B. Syed,Hayley Cuthbert,Livia E. Crica,Neus Lozano,Emmanuel Okwelogu,Jennifer B. Raftis,Lorraine Bruce,Craig A. Poland,Rodger Duffin,Paul H. B. Fokkens,A. John F. Boere,Daan L. A. C. Leseman,Ian L. Megson,Phil D. Whitfield,Kerstin Ziegler,Seshu Tammireddy,Marilena Hadjidemetriou,Cyrill Bussy,Flemming R. Cassee,David E. Newby,Kostas Kostarelos & Mark R. Miller
Nature Nanotechnology Published:16 February 2024
DOI:https://doi.org/10.1038/s41565-023-01572-3
Abstract
Graphene oxide nanomaterials are being developed for wide-ranging applications but are associated with potential safety concerns for human health. We conducted a double-blind randomized controlled study to determine how the inhalation of graphene oxide nanosheets affects acute pulmonary and cardiovascular function. Small and ultrasmall graphene oxide nanosheets at a concentration of 200 μg m–3 or filtered air were inhaled for 2 h by 14 young healthy volunteers in repeated visits. Overall, graphene oxide nanosheet exposure was well tolerated with no adverse effects. Heart rate, blood pressure, lung function and inflammatory markers were unaffected irrespective of graphene oxide particle size. Highly enriched blood proteomics analysis revealed very few differential plasma proteins and thrombus formation was mildly increased in an ex vivo model of arterial injury. Overall, acute inhalation of highly purified and thin nanometre-sized graphene oxide nanosheets was not associated with overt detrimental effects in healthy humans. These findings demonstrate the feasibility of carefully controlled human exposures at a clinical setting for risk assessment of graphene oxide, and lay the foundations for investigating the effects of other two-dimensional nanomaterials in humans. Clinicaltrials.gov ref: NCT03659864.
