クリミア・コンゴ出血熱ウイルスに対する新たな防御抗体標的を同定(Novel protective antibody target identified against Crimean Congo Hemorrhagic Fever virus)

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2024-02-27 カリフォルニア大学リバーサイド校(UCR)

米国陸軍感染症医学研究所(USAMRIID)率いる研究チームは、クリミア・コンゴ出血熱ウイルス(CCHFV)に対する重要な保護抗体の標的を発見した。UCリバーサイド医学部のスコット・ペガン教授も参加し、Nature Communications誌に発表された。彼らの研究は、感染患者に対する保護抗体の開発に道を開く可能性がある。

<関連情報>

ヌクレオカプシドタンパク質特異的モノクローナル抗体がクリミア・コンゴ出血熱ウイルスからマウスを守る Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Aura R. Garrison,Vanessa Moresco,Xiankun Zeng,Curtis R. Cline,Michael D. Ward,Keersten M. Ricks,Scott P. Olschner,Lisa H. Cazares,Elif Karaaslan,Collin J. Fitzpatrick,Éric Bergeron,Scott D. Pegan &Joseph W. Golden
Nature Communications  Published:26 February 2024
DOI:https://doi.org/10.1038/s41467-024-46110-4

クリミア・コンゴ出血熱ウイルスに対する新たな防御抗体標的を同定(Novel protective antibody target identified against Crimean Congo Hemorrhagic Fever virus)

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV. Most efforts have focused on targeting the viral glycoproteins. However, glycoproteins are poorly conserved among viral strains. The CCHFV nucleocapsid protein (NP) is highly conserved between CCHFV strains. Here, we investigate the protective efficacy of a CCHFV monoclonal antibody targeting the NP. We find that an anti-NP monoclonal antibody (mAb-9D5) protected female mice against lethal CCHFV infection or resulted in a significant delay in mean time-to-death in mice that succumbed to disease compared to isotype control animals. Antibody protection is independent of Fc-receptor functionality and complement activity. The antibody bound NP from several CCHFV strains and exhibited robust cross-protection against the heterologous CCHFV strain Afg09-2990. Our work demonstrates that the NP is a viable target for antibody-based therapeutics, providing another direction for developing immunotherapeutics against CCHFV.

有機化学・薬学
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