より良い健康への道(Sniffing our way to better health)

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香りを利用した新しい治療法は病気を遅らせることができる New scent-based therapy can delay disease; has implications also for agricultural production

2024-02-27 カリフォルニア大学リバーサイド校(UCR)

カリフォルニア大学リバーサイド校の研究チームが、果物ハエを使った実験で、酵母が放出する微生物揮発性化合物であるジアセチルにさらされることで、ハエの触角の遺伝子発現に変化が見られたことを明らかにした。この成果は、ハエ、マウス、ヒト細胞を対象にした実験で得られたもので、ジアセチルがヒストン脱アセチル化酵素(HDAC)の阻害剤として作用し、がんや炎症性疾患、神経変性疾患の治療に応用できる可能性があることを示唆している。これにより、臭いに基づく治療法の新しい展開が期待される。

<関連情報>

HDACを阻害する環境臭物質への曝露による神経系での遺伝子発現の可塑性 Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

Sachiko Haga-Yamanaka,Rogelio Nunez-Flores,Christi A Scott,Sarah Perry,Stephanie Turner Chen,Crystal Pontrello,Meera G Nair,Anandasankar Ray
eLife  Published:Feb 27, 2024
DOI:https://doi.org/10.7554/eLife.86823.3

より良い健康への道(Sniffing our way to better health)

Abstract

Eukaryotes respond to secreted metabolites from the microbiome. However, little is known about the effects of exposure to volatiles emitted by microbes or in the environment that we are exposed to over longer durations. Using Drosophila melanogaster, we evaluated a yeast-emitted volatile, diacetyl, found at high levels around fermenting fruits where they spend long periods of time. Exposure to the diacetyl molecules in headspace alters gene expression in the antenna. In vitro experiments demonstrated that diacetyl and structurally related volatiles inhibited conserved histone deacetylases (HDACs), increased histone-H3K9 acetylation in human cells, and caused changes in gene expression in both Drosophila and mice. Diacetyl crosses the blood–brain barrier and exposure caused modulation of gene expression in the mouse brain, therefore showing potential as a neuro-therapeutic. Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a neuroblastoma cell line in culture. Exposure to diacetyl vapors slowed progression of neurodegeneration in a Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on histone acetylation, gene expression, and physiology in animals.

有機化学・薬学
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