仮想現実体験と脳電気刺激がPTSD治療に有望(Virtual reality exposure plus electric brain stimulation offers a promising treatment for PTSD)

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2024-03-06 ブラウン大学

新しい研究によれば、脳刺激とバーチャルリアリティ療法の組み合わせは、PTSDに苦しむ軍人を含む患者にとって有望な治療法であることが示された。ブラウン大学の研究者たちは、臨床試験でこの組み合わせ療法がPTSD症状の有意な軽減をもたらすことを発見し、その成果を『JAMA Psychiatry』に報告した。この治療法は、軍人にとって特に難しいとされるPTSDを効果的に治療できる可能性があるとされている。

<関連情報>

心的外傷後ストレス障害に対するバーチャルリアリティと経頭蓋直流電流刺激療法 無作為臨床試験 Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder A Randomized Clinical Trial

Mascha van ’t Wout-Frank, PhD; Amanda R. Arulpragasam, PhD; Christiana Faucher, BS; et al
JAMA Psychiatry  Published:March 6, 2024
DOI:10.1001/jamapsychiatry.2023.5661

仮想現実体験と脳電気刺激がPTSD治療に有望(Virtual reality exposure plus electric brain stimulation offers a promising treatment for PTSD)

Key Points

Question Can therapeutic exposure using virtual reality (VR) be augmented with simultaneously applied transcranial direct current stimulation (tDCS) to reduce symptoms of posttraumatic stress disorder (PTSD)?

Findings In this randomized clinical trial including 54 US military veterans with warzone-related trauma, active tDCS delivered during VR exposure significantly improved self-reported PTSD symptoms, reduced measures of autonomic arousal, and improved social functioning compared with sham stimulation during VR exposure. This trial replicated key findings from a prior pilot study.

Meaning These findings suggest that the use of combined VR exposure plus tDCS could be a promising treatment for warzone-related PTSD.

Abstract

Importance Posttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms.

Objective To test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related PTSD.

Design, Setting, and Participants This double-blind randomized clinical trial was conducted among US military veterans enrolled from April 2018 to May 2023 at a secondary care Department of Veterans Affairs hospital and included 1- and 3-month follow-up visits. Participants included US military veterans with chronic PTSD and warzone-related exposure, recruited via referral and advertisement. Patients in psychiatric treatment had to be on a stable regimen for at least 6 weeks to be eligible for enrollment. Data were analyzed from May to September 2023.

Intervention Participants were randomly assigned to receive 2-mA anodal tDCS or sham tDCS targeted to the ventromedial prefrontal cortex, during six 25-minute sessions of standardized warzone VR exposure, delivered over 2 to 3 weeks.

Main Outcomes and Measures The co–primary outcomes were self-reported PTSD symptoms, measured via the PTSD checklist for DSM-5 (PCL-5), alongside quality of life. Other outcomes included psychophysiological arousal, clinician-assessed PTSD, depression, and social/occupational function.

Results A total of 54 participants (mean [SD] age, 45.7 [10.5] years; 51 [94%] males) were assessed, including 26 in the active tDCS group and 28 in the sham tDCS group. Participants in the active tDCS group reported a superior reduction in self-reported PTSD symptom severity at 1 month (t = -2.27, P = .02; Cohen d = -0.82). There were no significant differences in quality of life between active and sham tDCS groups. Active tDCS significantly accelerated psychophysiological habituation to VR events between sessions compared with sham tDCS (F5,7689.8 = 4.65; P < .001). Adverse effects were consistent with the known safety profile of the corresponding interventions.

Conclusions and Relevance These findings suggest that combined tDCS plus VR may be a promising strategy for PTSD reduction and underscore the innovative potential of these combined technologies.

Trial Registration ClinicalTrials.gov Identifier: NCT03372460

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