研究者らが合成細胞開発に関する「創設文書」を作成(Researchers Develop ‘Founding Document’ on Synthetic Cell Development)

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2024-05-02 NASA

細胞は生命の基本単位で、科学者は生物プロセスを模倣する合成細胞を開発しています。合成細胞は病気の新たな治療法、長期宇宙飛行の支援、生命の起源の理解に役立つ可能性があります。最近の論文では、合成細胞の可能性と課題を説明し、革新のロードマップを示しました。合成細胞は食糧生産や医療の進歩を促進し、新しい生命形態の創造や地球外生命の可能性探求にも貢献します。

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合成細胞の構築・技術基盤から細胞体まで Building Synthetic Cells-From the Technology Infrastructure to Cellular Entities

Lynn J. Rothschild, Nils J. H. Averesch, Elizabeth A. Strychalski, Felix Moser, John I. Glass, Rolando Cruz Perez, Ibrahim O. Yekinni, Brooke Rothschild-Mancinelli, Garrett A. Roberts Kingman, Feilun Wu, Jorik Waeterschoot, Ion A. Ioannou, Michael C. Jewett, Allen P. Liu, Vincent Noireaux, Carlise Sorenson, and Katarzyna P. Adamala
ACS Synthetic Biology  Published:March 26, 2024
DOI:https://doi.org/10.1021/acssynbio.3c00724

Abstract

研究者らが合成細胞開発に関する「創設文書」を作成(Researchers Develop ‘Founding Document’ on Synthetic Cell Development)

The de novo construction of a living organism is a compelling vision. Despite the astonishing technologies developed to modify living cells, building a functioning cell “from scratch” has yet to be accomplished. The pursuit of this goal alone has─and will─yield scientific insights affecting fields as diverse as cell biology, biotechnology, medicine, and astrobiology. Multiple approaches have aimed to create biochemical systems manifesting common characteristics of life, such as compartmentalization, metabolism, and replication and the derived features, evolution, responsiveness to stimuli, and directed movement. Significant achievements in synthesizing each of these criteria have been made, individually and in limited combinations. Here, we review these efforts, distinguish different approaches, and highlight bottlenecks in the current research. We look ahead at what work remains to be accomplished and propose a “roadmap” with key milestones to achieve the vision of building cells from molecular parts.

生物工学一般
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