UCIの研究により、熱ストレスが重要な臓器に与える悪影響が明らかに(UC Irvine study shows damaging impact of heat waves on vital organs)


2024-04-08 カリフォルニア大学校アーバイン校(UCI)



高齢者における周期的熱波誘発性神経細胞障害は腸-肝臓-脳軸によって媒介される:トランスクリプトームプロファイリングアプローチ Periodic heat waves-induced neuronal etiology in the elderly is mediated by gut-liver-brain axis: a transcriptome profiling approach

Subhajit Roy,Punnag Saha,Dipro Bose,Ayushi Trivedi,Madhura More,Christina Lin,Jie Wu,Melanie Oakes & Saurabh Chatterjee
Scientific Reports  Published:08 May 2024

UCIの研究により、熱ストレスが重要な臓器に与える悪影響が明らかに(UC Irvine study shows damaging impact of heat waves on vital organs)


Heat stress exposure in intermittent heat waves and subsequent exposure during war theaters pose a clinical challenge that can lead to multi-organ dysfunction and long-term complications in the elderly. Using an aged mouse model and high-throughput sequencing, this study investigated the molecular dynamics of the liver-brain connection during heat stress exposure. Distinctive gene expression patterns induced by periodic heat stress emerged in both brain and liver tissues. An altered transcriptome profile showed heat stress-induced altered acute phase response pathways, causing neural, hepatic, and systemic inflammation and impaired synaptic plasticity. Results also demonstrated that proinflammatory molecules such as S100B, IL-17, IL-33, and neurological disease signaling pathways were upregulated, while protective pathways like aryl hydrocarbon receptor signaling were downregulated. In parallel, Rantes, IRF7, NOD1/2, TREM1, and hepatic injury signaling pathways were upregulated. Furthermore, current research identified Orosomucoid 2 (ORM2) in the liver as one of the mediators of the liver-brain axis due to heat exposure. In conclusion, the transcriptome profiling in elderly heat-stressed mice revealed a coordinated network of liver-brain axis pathways with increased hepatic ORM2 secretion, possibly due to gut inflammation and dysbiosis. The above secretion of ORM2 may impact the brain through a leaky blood–brain barrier, thus emphasizing intricate multi-organ crosstalk.