2024-09-03 カリフォルニア工科大学(Caltech)
<関連情報>
- https://www.caltech.edu/about/news/new-genetic-editing-technique-to-alter-the-traits-and-fates-of-wild-populations
- https://www.nature.com/articles/s41467-024-50992-9
メンデルDNAの塩基配列を変更するアレルセイルで野生個体群の形質と運命を変える Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails
Michelle L. Johnson,Bruce A. Hay & Maciej Maselko
Nature Communications Published:13 August 2024
DOI:https://doi.org/10.1038/s41467-024-50992-9
Abstract
Population-scale genome modification can alter the composition or fate of wild populations. Synthetic gene drives provide one set of tools, but their use is complicated by scientific, regulatory, and social issues associated with transgene persistence and flow. Here we propose an alternative approach. An Allele Sail consists of a genome editor (the Wind) that introduces DNA sequence edits, and is inherited in a Mendelian fashion. Meanwhile, the edits (the Sail) experience an arithmetic, Super-Mendelian increase in frequency. We model this system and identify contexts in which a single, low frequency release of an editor brings edits to a very high frequency. We also identify conditions in which manipulation of sex determination can bring about population suppression. In regulatory frameworks that distinguish between transgenics (GMO) and their edited non-transgenic progeny (non-GMO) Allele Sails may prove useful since the spread and persistence of the GM component can be limited.
