2024-09-27 カリフォルニア大学校アーバイン校(UCI)
<関連情報>
- https://news.uci.edu/2024/09/27/circadian-disruption-gut-microbiome-changes-linked-to-colorectal-cancer-progression/
- https://www.science.org/doi/10.1126/sciadv.ado1458
腸内時計の乱れが大腸癌における腸内細菌の異常増殖とバリア機能障害を引き起こす Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer
Rachel C. Fellows, Sung Kook Chun, Natalie Larson, Bridget M. Fortin, […], and Selma Masri
Science Advances Published: 27 Sep 2024
DOI:https://doi.org/10.1126/sciadv.ado1458
Abstract
Diet is a robust entrainment cue that regulates diurnal rhythms of the gut microbiome. We and others have shown that disruption of the circadian clock drives the progression of colorectal cancer (CRC). While certain bacterial species have been suggested to play driver roles in CRC, it is unknown whether the intestinal clock impinges on the microbiome to accelerate CRC pathogenesis. To address this, genetic disruption of the circadian clock, in an Apc-driven mouse model of CRC, was used to define the impact on the gut microbiome. When clock disruption is combined with CRC, metagenomic sequencing identified dysregulation of many bacterial genera including Bacteroides, Helicobacter, and Megasphaera. We identify functional changes to microbial pathways including dysregulated nucleic acid, amino acid, and carbohydrate metabolism, as well as disruption of intestinal barrier function. Our findings suggest that clock disruption impinges on microbiota composition and intestinal permeability that may contribute to CRC pathogenesis.
