2025-03-17 国立環境研究所,エバーラスティング・ネイチャー,北海道大学,岩手大学
<関連情報>
- https://www.nies.go.jp/whatsnew/2025/20250317/20250317.html
- https://www.hokudai.ac.jp/news/pdf/250317_pr2.pdf
- https://www.sciencedirect.com/science/article/abs/pii/S1532045625000080?via%3Dihub
DNA損傷がアオウミガメ由来細胞の高温死を引き起こす DNA damage triggers the death of green sea turtle-derived cells at high temperature
Masafumi Katayama, Satomi Kondo, Manabu Onuma, Shouta M.M. Nakayama, Tomokazu Fukuda
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Available online: 14 January 2025
DOI:https://doi.org/10.1016/j.cbpc.2025.110127
Graphical abstract
Highlights
- High temperature induces apoptotic cell death in green turtles.
- Heat stress results in the accumulation of DNA damage in green turtle cells.
- Heat stress-induced DNA damage can trigger cell death in green sea turtle cells.
- The green sea turtle cells mimic the individual-level response to temperature.
Abstract
As temperatures rise due to increasingly severe global warming, the effect of high temperatures on wildlife, including green sea turtles, is one of the issues that must be addressed to ensure the conservation of biodiversity. In the current study, we found that green sea turtle cell death due to apoptosis occurred at 37 °C, which suppressed cell proliferation. We also found that high temperature-induced heat stress led to the accumulation of DNA damage in green sea turtle cells. DNA damage is a key factor for the induction of apoptosis. Therefore, heat stress-mediated DNA damage can trigger green sea turtle cell apoptosis. Based on these results, we predict that high temperatures, such as 37 °C, would adversely impact green sea turtles, resulting in death or health-related challenges. Importantly, this information can facilitate the conservation of green sea turtles because cellular and molecular studies regarding the effects of global warming effects remain limited.
