2025-04-03 京都大学
<関連情報>
- https://www.kyoto-u.ac.jp/ja/research-news/2025-04-03
- https://www.kyoto-u.ac.jp/sites/default/files/2025-04/web_2504_Ikuta-04f20244785682c516011af35efaf8e7.pdf
- https://academic.oup.com/jimmunol/advance-article-abstract/doi/10.1093/jimmun/vkae064/8087019
脂肪組織の制御性T細胞におけるIL-7Rαシグナル伝達は全身のグルコースホメオスタシスに必須である IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis
Shizue Tani-ichi, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Akihiro Shimba, Aki Ejima, Takahiro Hara, Guangwei Cui, Tomonobu Kado, Shohei Hori …
The Journal of Immunology Published:19 March 2025
DOI:https://doi.org/10.1093/jimmun/vkae064
Graphical Abstract
Abstract
Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. Here, we show that IL-33R (ST2)–expressing Tregs in the visceral adipose tissue (VAT) express the IL-7Rα at high levels. Treg-specific IL-7Rα–deficient mice exhibited reduced adipose ST2+ Tregs and impaired glucose tolerance, whereas IL-7Rα was dispensable for Tregs in lymphoid tissues. Mice deficient in thymic stromal lymphopoietin (TSLP), an additional ligand for IL-7Rα, displayed a modest decrease in adipose ST2+ Tregs and a reduced accumulation of adipose eosinophils, accompanied by slightly impaired glucose tolerance. In the VAT, mesothelial cells expressed IL-7, whereas adipose stem cells and folate receptor β–expressing tissue-resident macrophages expressed TSLP. Thus, this study indicates the significance of IL-7Rα signaling in the maintenance of VAT Tregs and glucose homeostasis, revealing a novel role for IL-7 and TSLP in immunometabolism.
