2025-04-15 カロリンスカ研究所
<関連情報>
- https://news.ki.se/heart-valve-abnormality-is-associated-with-malignant-arrhythmias
- https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf195/8111482
僧帽弁輪接合部と僧帽弁逸脱:手術後の心室性不整脈の長期リスク Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery
Klara Lodin , Cristina Oliveira Da Silva , Anne Wang Gottlieb , Ivana Bulatovic , Andreas Rück , Isaac George , David J Cohen , Frieder Braunschweig , Peter Svenarud , Maria J Eriksson …
European Heart Journal Published:15 April 2025
DOI:https://doi.org/10.1093/eurheartj/ehaf195
Structured Graphical Abstract
Abstract
Background and Aims
Mitral valve prolapse (MVP) is associated with progressive mitral regurgitation (MR) requiring surgical correction. A subset of patients with MVP experience ventricular arrhythmias (VA), and mitral annular disjunction (MAD) has been reported as a risk factor. This study aimed to assess the long-term risk of VA in patients with MAD and MVP undergoing mitral valve surgery for MR.
Methods
Patients with MVP with moderate or severe degenerative MR undergoing mitral valve surgery (repair or replacement) in 2010–22 at Karolinska University Hospital were included. Mitral annular disjunction length, referring to true MAD, was measured at end systole on pre- and post-operative transthoracic echocardiography. The primary outcome consisted of VA including hospitalizations, outpatient visits or ablation for confirmed sustained or non-sustained ventricular tachycardia, or high burden of premature ventricular complexes and assessed from medical records.
Results
Of 599 patients undergoing mitral valve surgery, 96 (16%) had pre-operative MAD. The median MAD length was 8.0 [inter-quartile range (IQR) 5.0–10.0] mm. Compared with patients without MAD, patients with MAD were younger (55 ± 15 vs 63 ± 11 years), were more often women (31% vs 17%), and had more Barlow’s disease (70% vs 27%). Mitral annular disjunction was surgically corrected in all patients. During a median follow-up time of 5.4 (IQR 2.8–7.5) years, patients with pre-operative MAD had a higher risk of VA (hazard ratio adjusted for age and sex 3.33, 95% confidence interval 1.37–8.08) regardless of repair/replacement (Pinteraction = .18).
Conclusions
Mitral annular disjunction in patients with MVP and MR was associated with a three-fold increased long-term risk of VA post-mitral valve surgery, despite anatomical correction of MAD.
