2025-04-22 ロックフェラー大学
<関連情報>
- https://www.rockefeller.edu/news/37594-using-a-pea-sized-node-in-the-brain-to-potentially-treat-drug-addiction/
- https://www.sciencedirect.com/science/article/pii/S1043661823000907?via%3Dihub
ハベヌラを理解する: 感情と意欲を制御する回路の主要なノード Understanding the habenula: A major node in circuits regulating emotion and motivation
Jessica L. Ables, Kwanghoon Park, Inés Ibañez–Tallon
Pharmacological Research Available online: 16 March 2023
DOI:https://doi.org/10.1016/j.phrs.2023.106734
Graphical Abstract
Abstract
Over the last decade, the understanding of the habenula has rapidly advanced from being an understudied brain area with the Latin name ‘habena” meaning “little rein”, to being considered a “major rein” in the control of key monoaminergic brain centers. This ancient brain structure is a strategic node in the information flow from fronto-limbic brain areas to brainstem nuclei. As such, it plays a crucial role in regulating emotional, motivational, and cognitive behaviors and has been implicated in several neuropsychiatric disorders, including depression and addiction. This review will summarize recent findings on the medial (MHb) and lateral (LHb) habenula, their topographical projections, cell types, and functions. Additionally, we will discuss contemporary efforts that have uncovered novel molecular pathways and synaptic mechanisms with a focus on MHb-Interpeduncular nucleus (IPN) synapses. Finally, we will explore the potential interplay between the habenula’s cholinergic and non-cholinergic components in coordinating related emotional and motivational behaviors, raising the possibility that these two pathways work together to provide balanced roles in reward prediction and aversion, rather than functioning independently.
