2025-04-29 トロント大学(U of T)
<関連情報>
- https://www.utoronto.ca/news/skin-based-test-could-improve-diagnosis-debilitating-neurodegenerative-disease
- https://jamanetwork.com/journals/jamaneurology/article-abstract/2824066
- https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28912
進行性核上性麻痺患者の皮膚における4反復タウ播種 Four-Repeat Tau Seeding in the Skin of Patients With Progressive Supranuclear Palsy
Ivan Martinez-Valbuena, PhD; M. Carmela Tartaglia, MD; Susan H. Fox, MD, PhD; et al
JAMA Neurology Published:September 23, 2024
DOI:10.1001/jamaneurol.2024.3162
The emergence of α-synuclein seeding amplification assays (SAA) has provided a new tool to support a clinical diagnosis of Parkinson disease (PD) and multiple system atrophy (MSA). This technology enables the detection of aggregated forms of α-synuclein (the neuropathologic hallmark of these diseases) in brain, cerebrospinal fluid, and in peripheral tissues, such as skin.
多系統萎縮症とパーキンソン病を区別するための皮膚αシヌクレインリアルタイムクエイキング誘導変換と循環神経フィラメント軽鎖の組み合わせ Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson’s Disease
Ivan Martinez-Valbuena PhD, Naomi P. Visanji PhD, Diana A. Olszewska MD, PhD, Mario Sousa MD, Puja Bhakta BSc, Anna Vasilevskaya BSc, Chloe Anastassiadis MSc …
Movement Disorders Published: 12 January 2022
DOI:https://doi.org/10.1002/mds.28912
