2025-05-13 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202505/t20250514_1043603.shtml
- https://www.the-innovation.org/article/doi/10.59717/j.xinn-life.2025.100132
エクソソームとオートファジーの細胞内・細胞間クロストーク Intracellular and intercellular crosstalk between exosomes and autophagy
Qilong Li,, Sisi Chen,, Yunju Yin, Mengmeng Han, Hanjing Shi, Yu Gong, Xinyue Duan,, Yonglang Wang,, Qiuping Guo, Yehui Duan, Yulong Yin,, Fengna Li
The Innovation Life Published:25 April 2025
DOI:https://doi.org/10.59717/j.xinn-life.2025.100132
GRAPHICAL ABSTRACT
PUBLIC SUMMARY
- The homeostatic role between exosomes and autophagy depends on the intracellular and intercellular crosstalk.
- Their intracellular connections intersect through shared molecular machinery or organelle.
- Exosomal miRNAs and proteins activate or inhibit autophagy-related signals to mediate intercellular crosstalk.
ABSTRACT
The intracellular and intercellular information exchange is the key to regulate the body function. Current studies have indicated the intracellular and intercellular crosstalk between exosomes and autophagy as two components of the eukaryotic endomembrane system. Exosomes are bilayer lipid membrane vesicles to participate in intercellular communication. Autophagy is to form autophagosome, then fuse with lysosome to degrade contents encapsulating cytoplasmic components. Exosomes and autophagy not only intersect through common molecular mechanism or organelle within cells, but also could activate intracellular autophagy-related signaling pathways to demonstrate the therapeutic potentiality of various diseases via exosomal miRNAs and proteins. The intracellular and intercellular crosstalk of them serves a homeostatic role in mitigating stress. What has become clear is that the steady state of this interaction is of great significance in physiology and pathology. If we could better understand the crosstalk from more perspectives, such as the function of exosomal lipids in regulating autophagy, the use of invertebrates as research models and the relationship between exosomes and selective autophagy of organelle-level, this represents an opportunity for treatment, especially the application of engineered exosomes.
