2025-05-15 東京大学
<関連情報>
循環血小板の包括的画像ベースのプロファイリングによる冠動脈疾患における抗血小板療法の直接的評価 Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets
Kazutoshi Hirose,Satoshi Kodera,Masako Nishikawa,Masataka Sato,Yuqi Zhou,Hongqian Zhang,Shun Minatsuki,Junichi Ishida,Norifumi Takeda,Huidong Wang,Chuiming Kong,Yunjie Deng,Junyu Chen,Chenqi Zhang,Jun Akita,Yuma Ibayashi,Ruoxi Yang,Hiroshi Kanno,Nao Nitta,Takeaki Sugimura,Norihiko Takeda,Makoto Kurano,Yutaka Yatomi & Keisuke Goda
Nature Communications Published:15 May 2025
DOI:https://doi.org/10.1038/s41467-025-59664-8
Abstract
Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditional platelet function measurement methods cannot directly evaluate its efficacy and safety. Here we demonstrate comprehensive image-based profiling of circulating platelets to directly observe thrombotic conditions and assess antiplatelet therapy in CAD patients. Deep learning-based analysis of whole blood samples from 207 CAD patients revealed elevated concentrations of circulating platelet aggregates, especially in acute versus chronic coronary syndrome patients. It also indicated a regimen-dependent reduction in these concentrations upon treatment with antiplatelet drugs, thereby verifying the direct efficacy of the therapy. Notably, consistent concentrations of these aggregates were found in both venous and arterial blood, suggesting venous blood as a reliable therapy efficacy indicator, despite CAD’s arterial nature. These findings support personalized and improved antiplatelet therapy in CAD management.
