遺伝子変異がロングCOVIDリスクを高める(A gene variant increases the risk of long COVID)

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2025-05-21 カロリンスカ研究所(KI)

スウェーデンのカロリンスカ研究所を中心とする国際研究チームは、ロングCOVIDの発症リスクを約60%高める遺伝子変異を特定しました。この変異は肺の発達や疾患に関与するFOXP4遺伝子の近くに位置し、16カ国から集めた6,450人の患者と100万人以上の対照群を対象とした解析により関連性が確認されました。FOXP4は肺機能に重要な役割を果たし、変異がロングCOVIDの発症に関与している可能性があります。今後の予防や治療法開発に貢献する成果です。

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長期COVIDのゲノムワイド関連研究 Genome-wide association study of long COVID

Vilma Lammi,Tomoko Nakanishi,Samuel E. Jones,Shea J. Andrews,Juha Karjalainen,Beatriz Cortés,Heath E. O’Brien,Ana Ochoa-Guzman,Brian E. Fulton-Howard,Martin Broberg,Hele H. Haapaniemi,Masahiro Kanai,Matti Pirinen,Axel Schmidt,Ruth E. Mitchell,Abdou Mousas,Massimo Mangino,Alicia Huerta-Chagoya,Nasa Sinnott-Armstrong,Elizabeth T. Cirulli,Marc Vaudel,Alex S. F. Kwong,Amit K. Maiti,Minttu M. Marttila,Long COVID Host Genetics Initiative,FinnGen,VA Million Veteran Program,MexGen-COVID Initiative,DBDS Genomic Consortium,GEN-COVID Multicenter Study,PHOSP-COVID Collaborative Group,GENCOV Study,Estonian Biobank Research Team,… Hanna M. Ollila
Nature Genetics  Published:21 May 2025
DOI:https://doi.org/10.1038/s41588-025-02100-w

遺伝子変異がロングCOVIDリスクを高める(A gene variant increases the risk of long COVID)

Abstract

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

医療・健康
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