2025-06-26 中国科学院(CAS)
Oral betaine effectively alleviates renal fibrosis in aged mice. Control group (left); Intervention group (right). (Image by Prof. LIU Guanghui’s lab)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202506/t20250626_1046232.shtml
- https://www.cell.com/cell/abstract/S0092-8674(25)00635-X
システマティック・プロファイリングにより、ベタインが老化予防のための運動模倣物質であることが明らかになった Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Lingling Geng ∙ Jiale Ping ∙ Ruochen Wu ∙ … ∙ Weiqi Zhang ∙ Jing Qu,,,,, ∙ Guang-Hui Liu
Cell Published:June 25, 2025
DOI:https://doi.org/10.1016/j.cell.2025.06.001
Highlights
•Systematic molecular blueprint of how exercise reshapes human homeostasis
•Repeated exercise boosts circulating betaine partly via renal synthesis
•Betaine inhibits TBK1, reducing senescence and inflammation
•Betaine exerts multi-organ geroprotection in aged mice
Summary
Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute exercise induced transient responses, whereas repeated exercise triggered adaptive changes, notably reducing cellular senescence and inflammation and enhancing betaine metabolism. Exercise-driven betaine enrichment, partly mediated by renal biosynthesis, exerts geroprotective effects and rescues age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), retarding the kinetics of aging. These findings systematically elucidate the molecular benefits of exercise and position betaine as an exercise mimetic for healthy aging.
