毒性とは程遠い乳酸塩は、炭水化物食後の身体の主要燃料としてグルコースに匹敵する(Far from toxic, lactate rivals glucose as body’s major fuel after a carbohydrate meal)

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2024-05-14 カリフォルニア大学バークレー校(UCB)

高校時代、ロバート・レイハはトレーニング中の乳酸蓄積がパフォーマンス低下の原因だと考えていました。しかし、大学での学びを通じて、乳酸は酸素不足のサインではなく、運動中に筋肉を燃料供給する正常な代謝産物であると理解しました。現在、カリフォルニア大学バークレー校での研究で、炭水化物摂取後に乳酸が迅速に血流に入り、血糖値の管理に重要な役割を果たすことを明らかにしました。研究結果は、スポーツ医学や糖尿病などの医療分野に新たな視点を提供し、乳酸の重要性を再評価するものです。

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ヒトにおける腸および全身の食後乳酸シャトルフェーズと食事炭水化物の炭素フロー Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans

Robert G. Leija,Casey C. Curl,Jose A. Arevalo,Adam D. Osmond,Justin J. Duong,Melvin J. Huie,Umesh Masharani & George A. Brooks
Nature Metabolism  Published:22 February 2024
DOI:https://doi.org/10.1038/s42255-024-00993-1

毒性とは程遠い乳酸塩は、炭水化物食後の身体の主要燃料としてグルコースに匹敵する(Far from toxic, lactate rivals glucose as body’s major fuel after a carbohydrate meal)

Abstract

Dietary glucose in excess is stored in the liver in the form of glycogen. As opposed to direct conversion of glucose into glycogen, the hypothesis of the postprandial lactate shuttle (PLS) proposes that dietary glucose uptake is metabolized to lactate in the gut, thereby being transferred to the liver for glycogen storage. In the present study, we provide evidence of a PLS in young healthy men and women. Overnight fasted participants underwent an oral glucose tolerance test, and arterialized lactate concentration and rate of appearance were determined. The concentration of lactate in the blood rose before the concentration of glucose, thus providing evidence of an enteric PLS. Secondary increments in the concentration of lactate in the blood and its rate of appearance coincided with those of glucose, which indicates the presence of a larger, secondary, systemic PLS phase driven by hepatic glucose release. The present study challenges the notion that lactate production is the result of hypoxia in skeletal muscles, because our work indicates that glycolysis proceeds to lactate in fully aerobic tissues and dietary carbohydrate is processed via lactate shuttling. Our study proposes that, in humans, lactate is a major vehicle for carbohydrate carbon distribution and metabolism.

医療・健康
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