2025-07-09 マウントサイナイ医療システム (MSHS)
<関連情報>
- https://www.mountsinai.org/about/newsroom/2025/prenatal-and-childhood-lead-exposure-linked-to-faster-memory-decay-in-children
- https://www.science.org/doi/10.1126/sciadv.adq4495
発達期の鉛被曝はメキシコの子どもたちの遅発性照合課題での忘却率を増加させる Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children
Katherine Svensson, Jamil M. Lane, John J. Chelonis, Chris Gennings, […] , and Robert O. Wright
Science Advances Published:9 Jul 2025
DOI:https://doi.org/10.1126/sciadv.adq4495
Abstract
Lead (Pb) is a potent neurotoxicant, but few studies have evaluated its effect on neurobehavioral measures that can be used in multiple species including humans. We investigated the effect of prenatal and childhood Pb exposure on children’s rate of forgetting using a delayed matching-to-sample (DMTS) task among children 6 to 8 years of age. Blood Pb was measured during pregnancy (second and third trimesters) and at 4 to 6 years of age. A nonlinear modified power function was used to predict the forgetting rates on the DMTS task, using separate models for prenatal and childhood Pb. Higher childhood Pb [median (interquartile range), 1.7 (1.3) (μg/dl)] was associated with a faster rate of forgetting (β = -0.05; 95% confidence interval: -0.09, -0.01). Higher maternal intelligence quotient and child’s age were significantly associated with a slower rate of forgetting. We validated a unique power function statistical approach for rates of forgetting using Pb exposure.
