2025-08-26 バース大学
<関連情報>
- https://www.bath.ac.uk/announcements/largest-ever-study-into-cannabis-use-and-mental-health-unveiled/
- https://mentalhealth.bmj.com/content/28/1/e301810
- https://www.cambridge.org/core/journals/psychological-medicine/article/impact-of-childhood-trauma-and-cannabis-use-on-paranoia-a-structural-equation-model-approach/C45E859EF82FC9F9EFB07AF36441BFEC
初回大麻使用の動機は、その後の大麻消費量(標準THC単位)および精神病理と関連するか? Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?
Edoardo Spinazzola,Hannah Degen,Isabelle Austin-Zimmerman,Giulia Trotta,…
BMJ Mental Health Published:26 August 2025
Abstract
Background Reasons for first using cannabis (RFUC) may influence later use patterns and mental health outcomes. However, limited research has explored self-medication versus social RFUCs in depth, and their associations with cannabis use patterns and psychopathology in the general population.
Objectives We examined RFUCs and their associations with (1) reasons for continuing cannabis use, (2) weekly THC (delta-9-tetrahydrocannabinol) unit consumption and (3) symptoms of paranoia, anxiety and depressive symptoms.
Methods We analysed data from the Cannabis&Me (CAMe) population survey (March 2022–July 2024), including 2573 (75.9%) current and 816 (24.1%) past cannabis users aged 18 years or older.
Findings Participants reported a mean weekly consumption of 206 THC units (SD=268). Initiating cannabis use for anxiety (β=36.22, p=3.3e-03), depression (β=40.37, p=1.74e-03) or because ‘family members were using it’ (β=87.43, p=1.22e-09) was associated with higher weekly THC units. RFUC to relieve physical discomfort (β=8.89, p=4.12e-07), pain (β=7.24, p=5.56e-06), anxiety (β=9.67, p=1.63e-16), depression (β=9.12, p=1.21e-13) and minor psychotic symptoms (β=16.46, p=1.2e-04) were linked to higher paranoia scores. Similar associations were observed for anxiety and depression. Conversely, starting for fun (β=-3.71, p=3.49e-05) or curiosity (β=-2.61, p=5e-03) was associated with lower paranoia and anxiety. RFUC for ‘boredom’ was linked to increased depression (β=1.09, p=3.8e-03).
Conclusions Initiating cannabis use for self-medication is associated with higher average THC consumption, and increased anxiety, depression and paranoia.
Clinical implications Asking individuals why they first used cannabis may serve as a cost-effective screening tool to identify those who could benefit from monitoring, support, or referral to intervention services.
小児期のトラウマと大麻使用が妄想に与える影響:構造方程式モデルによるアプローチ The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach
Giulia Trotta,Edoardo Spinazzola,Hannah Degen,Zhikun Li,Isabelle Austin-Zimmerman,Bok Man Leung,Yifei Lang,Victoria Rodriguez,Monica Aas and Lucia Sideli,…
Psychological Medicine Published:08 August 2025
DOI:https://doi.org/10.1017/S0033291725101190
Abstract
Background
Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure.
Methods
Data were derived from the Cannabis&Me study, an observational, cross-sectional, online survey of 4,736 participants. Childhood trauma was assessed using a modified Childhood Trauma Screen Questionnaire, while paranoia was measured via the Green Paranoid Thoughts Scale. Cannabis use was quantified using weekly standard THC units. Structural equation modeling (SEM) was employed to evaluate direct and indirect pathways between trauma, cannabis use, and paranoia.
Results
Childhood trauma was strongly associated with paranoia, particularly emotional, and physical abuse (β = 16.10, q < 0.001; β = 16.40, q < 0.001). Cannabis use significantly predicted paranoia (β = 0.009, q < 0.001). Interactions emerged between standard THC units and both emotional abuse (β = 0.011, q < 0.001) and household discord (β = 0.011, q < 0.001). SEM revealed a small but significant indirect effect of trauma on paranoia via cannabis use (β = 0.004, p = 0.017).
Conclusions
These findings highlight childhood trauma as a primary driver of paranoia, with cannabis use amplifying its effects. While trauma had a strong direct impact, cannabis played a significant mediating role. Integrating standard THC units into psychiatric research and clinical assessments may enhance risk detection and refine intervention strategies, particularly for childhood trauma-exposed individuals.
