2025-11-04 東京大学
時間差二段階反応のイメージ図
<関連情報>
- https://www.t.u-tokyo.ac.jp/press/pr2025-11-04-001
- https://www.t.u-tokyo.ac.jp/hubfs/press-release/2025/1104/001/text.pdf
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202503518
肝切除に伴う胆汁漏出を効果的に予防する新規合成ハイドロゲルシーラントの開発 Development of a Novel Synthetic Hydrogel Sealant for Effective Prevention of Liver Resection-Associated Bile Leakage
Kazuyoshi Matsubara, Shohei Ishikawa, Hiroyuki Kamata, Almog Gur, Ayano Fujisawa, Shu Nishida, Katsuyuki Hoshina, Takamasa Sakai
Advanced Healthcare Materials Published: 03 November 2025
DOI:https://doi.org/10.1002/adhm.202503518
Abstract
Bile leakage is a major complication following hepatectomy; these often lead to surgical site infections, liver failure, and even death. Biomaterials, including fibrinogen-based collagen fleece (TachoSil) and fibrin glue, are ineffective for bile sealing. Synthetic sealants, including cyanoacrylate and polymer-based materials, independent of coagulation, are inadequate for bile leakage management. Therefore, in the present study, a novel hydrogel-based sealant (DCSN_100_25) is developed using 3 types of poly(ethylene glycol) (PEG) with a dual-stage cross-linking mechanism, termed the delayed cross-linked single network (DCSN). This design facilitates rapid initial solidification followed by gradual network formation, ensuring immediate sealing and stable adhesion to the amputated liver tissue surface. Experiments using in vivo rat hepatectomy models demonstrated that DCSN_100_25 achieved hemostasis within 1 min, outperforming conventional sealants, such as SURGICEL and TachoSil, and effectively preventing both bleeding and bile leakage. Furthermore, in vivo safety assessments confirmed its safety profile, with PEG brushes remaining on the liver tissue and exhibiting minimal inflammation and no chronic liver damage. These findings suggest that DCSN_100_25 is a promising surgical sealant that effectively manages bile leakage and enhances hepatectomy safety.
