2025-12-10 愛媛大学
<関連情報>
- https://www.ehime-u.ac.jp/data_relese/pr_20251210_med/
- https://www.ehime-u.ac.jp/wp-content/uploads/2025/12/pr_20251210_med.pdf
- https://www.nature.com/articles/s41440-025-02417-3
高血圧性認知症における科学的意義のある最新の基礎研究の最新情報
Current updates on latest basic research of scientific relevance in hypertensive dementia
Masaki Mogi,Yoichi Takami,Masafumi Ihara,Toru Yamashita,Shuko Takeda,Shigeru Shibata,Kouichi Node,Kazuomi Kario & Prevention of Cognitive Impairment by Hypertension Management (PCIHM) Working Group of the Japanese Society of Hypertension
Hypertension Research Published:05 November 2025
DOI:https://doi.org/10.1038/s41440-025-02417-3
In Japan, there is an urgent need to respond to dementia, and the Basic Act on Dementia to Promote an Inclusive Society [1] was enacted in January 2024. Among the basic policies, the importance of promoting research on dementia and preventing dementia is emphasized. Hypertension is one of the modifiable risk factors for dementia, and, in particular, midlife hypertension is attracting attention from an epidemiological perspective [2]. It has become clear that hypertension-induced dementia (“hypertensive dementia”) is associated with disturbance in the balance of the neurovascular unit (NVU), which is composed of the three elements of blood vessels, astrocytes, and neurons, in not only vascular dementia (VaD) but also Alzheimer’s disease (AD) [3]; thus, it has been proposed that the accumulation of cardiovascular burden over the life course induces dementia in older age [4]. Although the concept of “hypertensive dementia” has been established clinically, basic research is also progressing to elucidate the mechanisms and to find emerging concepts in particular, since the American Heart Association issued a scientific statement on blood pressure and dementia in 2016 [5]. After introducing the statement, a number of papers related to hypertensive dementia have been reported each year, and attention to this condition has been increasing. The Japanese Society of Hypertension has focused on the importance of hypertension management for the prevention of dementia, and established the Prevention of Cognitive Impairment by Hypertension Management (PCIHM) Working Group to investigate the relationship between hypertension and dementia through both basic and clinical research. This review summarizes the latest developments in basic research on hypertensive dementia. We hope that this will be useful not only for basic researchers in dementia but also for general practitioners who treat hypertension worldwide.
