2026-01-22 マウントサイナイ医療システム(MSHS)
<関連情報>
- https://www.mountsinai.org/about/newsroom/2026/new-study-links-altered-cellular-states-to-brain-structure
- https://www.cell.com/cell/fulltext/S0092-8674(25)01179-1
脳細胞の老化と脳構造の関係を確立する Establishing the relationship between brain cellular senescence and brain structure
Anina N. Lund ∙ Brian H. Kopel ∙ Negar Golestani ∙ … ∙ Eric E. Schadt ∙ Alexander W. Charney ∙ Noam D. Beckmann
Cell Published:January 22, 2026
DOI:https://doi.org/10.1016/j.cell.2025.10.014
Graphical abstract
Highlights
- Prefrontal cortex gene expression patterns associate with brain-wide structural features
- Cell-type-specific senescence and brain structure gene expression reveal shared biology
- Excitatory neuron and microglial senescence show opposing brain volume associations
- Senescence-brain structure relationships persist in both development and aging
Summary
Cellular senescence and brain atrophy are both associated with brain aging, suggesting these processes may share underlying biological mechanisms. This study investigated these mechanisms by integrating structural neuroimaging with gene and protein expression data from prefrontal cortex tissue collected from individuals who underwent neurosurgery. Cell-type-specific gene expression signatures associated with neuroimaging features and cellular senescence were identified and replicated in several independent datasets. Significant correlations between these signatures were observed in excitatory neurons and microglia, especially for volume-related features. These associations were also observed for excitatory neurons in an independent brain gene expression dataset from individuals below 5 years of age, implying a role for senescence during brain development. Together, this study provides a deep characterization of molecular signatures linking brain structure and cellular senescence across different life stages and suggests mechanisms supporting brain development may also contribute to volume reduction observed during aging.
