2026-03-17 トロント大学（U of T）
(photo by Stefan Tomic/Getty Images)
＜関連情報＞
- https://www.utoronto.ca/news/sucrose-effective-way-help-manage-painful-procedures-babies-study
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015221.pub2/full
新生児の静脈穿刺時のスクロース鎮痛 Sucrose analgesia for venepuncture in neonates
Mariana Bueno,Ligyana Candido,Jiale Hu,Michelle Fiander,Jane Cracknell,Emily Xu,Jiamin Kang,Janet Yamada,Supported by the Cochrane Neonatal Group
Cochrane Database of Systematic reviews Published: 04 March 2026
DOI:https://doi.org/10.1002/14651858.CD015221.pub2
Abstract
Rationale
Sucrose is, in general, safe and effective for analgesia during venepuncture in hospitalised neonates. However, there is a lack of evidence on its analgesic effects.
Objectives
To evaluate the benefits and harms of orally administered sucrose for pain relief from venepuncture in preterm and term neonates compared to no intervention, standard care, and other types of analgesic interventions.
Search methods
We searched CENTRAL, MEDLINE, Ovid Embase, and trial registries in July 2025, and the China National Knowledge Infrastructure, VIP Chinese Science and Technology Periodicals, and Wanfang Data in August 2024. We checked reference lists of included studies and topic‐related systematic reviews.
Eligibility criteria
We included randomised controlled trials (RCTs), including cross‐over and cluster‐RCTs, that evaluated the effects of sucrose analgesia in neonates (including term and preterm infants) up to 44 weeks’ postmenstrual age undergoing venepuncture. We excluded quasi‐RCTs and studies reported only as conference abstracts. We included studies administering sucrose with or without non‐nutritive sucking (NNS) before, at the time of, or after venepuncture. Sucrose could be of any concentration, volume, or dose. Sucrose was compared to: no intervention, water, or standard care; skin‐to‐skin care; breastfeeding; feeding; NNS alone (e.g. pacifier); glucose; positioning; or topical anaesthetics.
Outcomes
Outcomes of interest were pain intensity score, as measured by validated pain assessment scales, and adverse events.
