2026-03-31 フランス国立科学研究センター（CNRS）
＜関連情報＞
- https://www.cnrs.fr/en/press/crimean-congo-haemorrhagic-fever-mechanism-viral-dissemination-has-been-deciphered
- https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2645855
クリミア・コンゴ出血熱ウイルスは、ウイルス粒子産生のために肝臓の脂質代謝経路を乗っ取る The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production
Anupriya Gautam,Li Zhong,Eva Ogire,Sergueï Bodoirat,Ilary Riedmiller,Willem J. Sandera ,…
Emerging Microbes & Infections Published:30 Mar 2026
DOI:https://doi.org/10.1080/22221751.2026.2645855
ABSTRACT
The Crimean-Congo Haemorrhagic Fever Virus (CCHFV), a tri-segmented negative-strand virus that belongs to the Orthonairovirus genus, is highly pathogenic in humans but not in other host species. Following infection in humans, CCHFV disseminates widely but replicates most strongly in hepatocytes, indicating a preferential liver tropism. As hepatocytes are the primary site for production and secretion of lipids, here we sought to characterize the interplay between CCHFV and lipoprotein metabolism in hepatocytes. First, we found that CCHFV particles display a heterogeneous profile of density, suggesting various virion compositions. Next, we showed that several lipoprotein components are associated with viral particles. Additionally, we found that pharmacological inhibition or down-regulation of the host factors involved in lipoprotein biogenesis and lipid metabolism could impair CCHFV infection. Our results, therefore, by revealing a close interplay between liver lipid metabolism and CCHFV, highlight the potential of repurposing existing lipid-modulating drugs and allow designing new interventions to curb CCHFV infections.
