2026-08-07 カリフォルニア大学アーバイン校（UCI）
＜関連情報＞
- https://news.uci.edu/2026/08/07/different-inflammatory-processes-tied-to-the-same-alzheimers-disease-related-brain-shrinkage-and-memory-loss/
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70415
アルツハイマー病における脳血管障害とアミロイドβへの並行する神経炎症経路 Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer’s disease
Batool Rizvi, Jenna N. Adams, Alison Bamford, Soyun Kim, Mithra Sathishkumar, Nicholas J. Tustison, Lisa Taylor, Nandita Tuteja, Liv McMillan, Bin Nan, …
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Published: 07 August 2026
DOI:https://doi.org/10.1002/dad2.70415
Abstract
INTRODUCTION
Upstream neuroinflammation plays an important role in Alzheimer’s disease (AD) but remains poorly understood. We tested whether two distinct neuroinflammatory markers are associated with cerebrovascular burden and amyloid beta (Aβ), and downstream, with plasma phosphorylated tau (p-tau217), medial temporal lobe (MTL) cortical and hippocampal atrophy, and memory deficits.
METHODS
Cognitively unimpaired older adults without dementia or mild cognitive impairment were recruited from a community sample (Biomarker Exploration in Aging, Cognition, and Neurodegeneration; [BEACoN]; N = 126). We used structural equation modeling to test whether plasma chitinase-3-like protein 1 (YKL-40) and glial fibrillary acidic protein (GFAP) contribute to distinct pathways.
RESULTS
Higher plasma YKL-40 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F-florbetapir (FBP) standardized uptake value ratio (SUVR). Higher plasma GFAP, WMH, and FBP SUVR were independently associated with increased p-tau217. Plasma p-tau217 was associated with reduced MTL cortical thickness and hippocampal volume. Reduced hippocampal volume was related to worse memory.
DISCUSSION
Future work can further investigate these neuroinflammatory pathways as potential therapeutic targets for AD.
Highlights
- Higher YKL-40 was linked to WMH, while higher GFAP was related to FBP SUVR.
- Higher plasma GFAP, WMH and FBP SUVR were associated with pTau-217.
- Higher pTau-217 was linked to lower MTL cortical thickness and hippocampal volume.
- Lower hippocampal volume was related to worse memory performance.
