2026-10-13 北海道大学,森永乳業株式会社,岩見沢市
本研究の概要図：妊娠中の食事と産後のαディフェンシン分泌量、腸内細菌叢、気分状態との関連
＜関連情報＞
- https://www.hokudai.ac.jp/news/2026/10/post-2463.html
- https://www.nature.com/articles/s44294-026-00164-5
産後の高いαディフェンシン分泌量は、妊娠中の食事及び母親のネガティブな気分状態の程度が低いことと関連する Higher postpartum α-defensin secretion is associated with diet during pregnancy and lower intensity of negative maternal mood
Yu Shimizu, Yuki Yokoi, Shuya Ohira, Hirohisa Izumi, Satomi Kawakami, Fuka Tabata, Hirohiko Nakamura, Yasuhiro Takeda, Takashi Kimura, Koshi Nakamura, Akiko Tamakoshi, Tokiyoshi Ayabe & Kiminori Nakamura
npj Women’s Health Published:27 August 2026
DOI:https://doi.org/10.1038/s44294-026-00164-5 Early provide
Abstract
Perinatal anxiety and depression are serious concerns for many mothers. However, current early-phase community-based care is not always sufficient to prevent their aggravation, necessitating self-care approaches through daily habits that lower social and psychological implementation barriers. α-Defensins secreted by small intestinal Paneth cells are known to affect mental state by modulating the intestinal microbiota, and dietary factors are associated with α-defensin secretion. Thus, we investigated the relationship between perinatal α-defensins (human defensin 5: HD5) and mood states, and explored dietary factors relating to HD5 secretion. In 48 mothers, higher fecal HD5 concentrations at 3-day postpartum were associated with lower intensity of negative mood states at 1-month postpartum. Higher HD5 correlated with characteristics of the intestinal microbiota related to lower intensity of negative mood. Furthermore, the intake of several nutrients during mid-pregnancy was associated with HD5. These findings may propose novel perspectives for promoting women’s health through dietary habits during pregnancy.
