2023-07-05 カロリンスカ研究所(KI)
◆この研究により、PCOSの根本的な原因は未だ不明ですが、アンドロゲンの過剰が症状の進行に関与していることが明らかになりました。PCOSは多くの女性に影響し、排卵や月経の不規則性、妊娠の合併症などを引き起こす可能性があります。研究者は、今後、PCOSにおける他の免疫細胞の影響を研究し、それが生殖と代謝機能に与える影響を解明する予定です。
<関連情報>
- https://news.ki.se/researchers-examine-role-of-b-cells-in-pcos
- https://elifesciences.org/articles/86454
多嚢胞性卵巣症候群の免疫細胞活性化におけるB細胞の役割 The role of B cells in immune cell activation in polycystic ovary syndrome
Angelo Ascani,Sara Torstensson,Sanjiv Risal,Haojiang Lu,Gustaw Eriksson,Congru Li,Sabrina Teschl,Joana Menezes,Katalin Sandor,Claes Ohlsson,Camilla I Svensson,Mikael CI Karlsson,Martin Helmut Stradner,Barbara Obermayer-Pietsch,Elisabet Stener-Victorin
eLife Published:Jul 4, 2023
DOI:https://doi.org/10.7554/eLife.86454
Abstract
Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here we demonstrate that B cells are not central mediators of PCOS pathology and that their frequencies are altered as a direct effect of androgen receptor activation. Hyperandrogenic women with PCOS have increased frequencies of age-associated double-negative B memory cells and increased levels of circulating immunoglobulin M (IgM). However, the transfer of serum IgG from women into wild-type female mice induces only an increase in body weight. Furthermore, RAG1 knock-out mice, which lack mature T- and B cells, fail to develop any PCOS-like phenotype. In wild-type mice, co-treatment with flutamide, an androgen receptor antagonist, prevents not only the development of a PCOS-like phenotype but also alterations of B cell frequencies induced by dihydrotestosterone (DHT). Finally, B cell-deficient mice, when exposed to DHT, are not protected from developing a PCOS-like phenotype. These results urge further studies on B cell functions and their effects on autoimmune comorbidities highly prevalent among women with PCOS.
