2024-01-25 ミシガン大学
◆AMHは卵巣の予備量を測定し、卵の数を示すバイオロジカルクロックのようなものであり、重金属との関連は喫煙と同等以上の強さを持っている。これは、女性の健康にとって重要な公衆衛生問題であり、将来の研究が必要である。
<関連情報>
- https://news.umich.edu/heavy-metals-are-toxic-to-ovaries-may-lead-to-earlier-menopause/
- https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad756/7582943
更年期移行期の重金属と抗ミュラーホルモンの軌跡 Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition
Ning Ding, Xin Wang, Siobán D Harlow, John F Randolph, Jr, Ellen B Gold, Sung Kyun Park
The Journal of Clinical Endocrinology & Metabolism Published:25 January 2024
DOI:https://doi.org/10.1210/clinem/dgad756
Abstract
Background
Experimental and epidemiological studies have linked metals with women’s reproductive aging, but the mechanisms are not well understood. Disrupted ovarian folliculogenesis and diminished ovarian reserve could be a pathway through which metals impact reproductive hormones and outcomes.
Objective
The study aimed to evaluate the associations of heavy metals with anti-Müllerian hormone (AMH), a marker of ovarian reserve.
Methods
The study included 549 women from the Study of Women’s Health Across the Nation with 2252 repeated AMH measurements from 10 to 0 years before the final menstrual period (FMP). Serum AMH concentrations were measured using picoAMH ELISA. Urinary concentrations of arsenic, cadmium, mercury, and lead were measured using high-resolution inductively coupled plasma mass spectrometry. Multivariable linear mixed regressions modeled AMH as a function of time before the FMP interaction terms between metals and time to the FMP were also included.
Results
Adjusting for confounders, compared with those in the lowest tertile, women in the highest tertile of urinary arsenic or mercury concentrations had lower AMH concentrations at the FMP (percent change: -32.1%; 95% CI, -52.9 to -2.2, P-trend = .03 for arsenic; percent change: -40.7%; 95% CI, -58.9 to -14.5, P-trend = .005 for mercury). Higher cadmium and mercury were also associated with accelerated rates of decline in AMH over time (percent change per year: -9.0%; 95% CI, -15.5 to -1.9, P-trend = .01 for cadmium; -7.3%; 95% CI, -14.0 to -0.1, P-trend = .04 for mercury).
Conclusion
Heavy metals including arsenic, cadmium, and mercury may act as ovarian toxicants by diminishing ovarian reserve in women approaching the FMP.
