母乳中にTHCが残存し、明確なピークポイントはない(THC lingers in breastmilk with no clear peak point)

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2024-05-08 ワシントン州立大学(WSU)

ワシントン州立大学の研究によると、授乳中の母親が大麻を使用すると、その精神活性成分であるTHCが母乳に現れることがわかりました。母乳中のTHC濃度のピークや減少開始の一貫した時間はなく、乳児が受け取るTHCの量は1日あたり平均0.07 mgで、影響は不明です。この研究は「Breastfeeding Medicine」誌に掲載され、20人の授乳中母親から寄付された母乳を分析しました。母乳中のTHCは、12時間の禁煙後も常に検出可能でした。この研究は、授乳中の大麻使用とその影響に関する知識のギャップを埋めるために行われています。

<関連情報>

ヒト乳汁中のカンナビノイド濃度と母体因子との関連: 授乳とカンナビス(LAC)研究 Human Milk Cannabinoid Concentrations and Associations with Maternal Factors: The Lactation and Cannabis (LAC) Study

Elizabeth A. Holdsworth, Anna Berim, David R. Gang, Janet E. Williams, Caroline B. Smith, Beatrice Caffé, Olivia Brooks, Celestina Barbosa-Leiker, Mark A. McGuire, Michelle K. McGuire , and Courtney L. Meehan
Breastfeeding Medicine  Published:2 May 2024
DOI:https://doi.org/10.1089/bfm.2024.0021

母乳中にTHCが残存し、明確なピークポイントはない(THC lingers in breastmilk with no clear peak point)

Abstract

Background and Objectives: As cannabis use increases among reproductive-aged women, there is a growing need to better understand the presence of cannabinoids in milk produced by women using cannabis. It is unclear how concentrations of cannabinoids such as delta-9-tetrahydrocannabinol (Δ9-THC) persist in milk after cannabis use and what factors contribute to variation in milk Δ9-THC concentrations. Our objectives were to measure cannabinoids in human milk following cannabis abstention, after single and repeated instances of cannabis use, and identify factors contributing to concentration variation.

Methods: The Lactation and Cannabis (LAC) Study prospectively observed 20 breastfeeding participants who frequently used cannabis (≥1/week), had enrolled <6 months postpartum, were feeding their infant their milk ≥5 times/day, and were not using any illicit drugs. Participants collected a baseline milk sample after ≥12 hours of abstaining from cannabis and five milk samples at set intervals over 8–12 hours after initial cannabis use. Participants completed surveys and recorded self-directed cannabis use during the study period.

Results: Δ9-THC peaked 120 minutes after a single instance of cannabis use (median, n = 9). More instances of cannabis use during the study period were associated with greater Δ9-THC area-under-the-curve concentrations (ρ = 0.65, p = 0.002), indicating Δ9-THC bioaccumulation in most participants. Baseline Δ9-THC logged concentration was positively associated with self-reported frequency of cannabis use (b = 0.57, p = 0.01).

Conclusions: Cannabinoids are measurable in human milk following cannabis use, and concentrations remain elevated with repeated cannabis use over a day. Substantial variation in Δ9-THC milk concentrations reflects individual differences in characteristics and behavior, including average postpartum frequency of cannabis use.

医療・健康
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