2026-09-30 英国研究イノベーション機構（UKRI）
＜関連情報＞
- https://www.ukri.org/news/experts-extend-lives-of-animals-by-activating-energy-saver-mode/
- https://onlinelibrary.wiley.com/doi/10.1111/acel.70721
AMPKの直接的な薬理学的活性化は、酵母、線虫、およびハエの寿命を延長する Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John-Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, …
Aging Cell Published: 29 September 2026
DOI:https://doi.org/10.1111/acel.70721
ABSTRACT
AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis and plays a central role in metabolic health and disease. AMPK has also been implicated in ageing; however, most in vivo drug studies rely on the use of indirect activators, such as metformin, which have complex modes-of-action, therefore making conclusions on the specific role of AMPK more challenging. Here, we demonstrate that direct activation of AMPK with the compound 991 extends lifespan in Drosophila melanogaster, Caenorhabditis elegans and Schizosaccharomyces pombe. In mice, 991 treatment induces a pro-longevity proteomic profile, highlighting the potential for translation to mammals. Overall, our study provides important proof-of-principle for AMPK as a pharmacological target with longevity benefits.
