免疫細胞がビタミンD吸収の手がかりを握っていることが示唆される(Immune cells hold clues to vitamin D absorption, study suggests)

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2023-03-08 ペンシルベニア州立大学(PennState)

ペンシルバニア州立大学の研究者たちは、マウスの免疫細胞を、ビタミンD受容体を持つか否かによって区別することができることを発見した。この発見は、ビタミンDの状態と潰瘍性大腸炎、クローン病、多発性硬化症などの自己免疫疾患の関連性をより理解することにつながる可能性がある

<関連情報>

ビタミンD受容体の発現が異なる2系統の免疫細胞 Two lineages of immune cells that differentially express the vitamin D receptor

Margherita T. Cantorna, Juhi Arora
The Journal of Steroid Biochemistry and Molecular Biology  Available online: 16 January 2023
DOI:https://doi.org/10.1016/j.jsbmb.2023.106253

Abstract

Since 1983 it has been known that monocytes and activated T and B cells expressed the vitamin D receptor (VDR) and are therefore vitamin D targets. New data identified two lineages of immune cells that can be differentiated by the expression of the VDR. Monocytes, macrophages, neutrophils, and hematopoietic stem cells were mostly from VDR positive lineages. T cells, ILC1 and ILC3 were also largely VDR positive, which is consistent with the known effects of vitamin D as regulators of type-1 and type-3 immunity. Activation of the VDR negative T cells did not induce the expression of the VDR reporter, suggesting that perhaps only a subset of the T cells in the periphery express the VDR. When activated, the VDR negative T cells responded as if they were VDR knockout T cells in that they made more IFN-γ and proliferated faster than the VDR positive T cells. The ability of vitamin D to regulate immune function will depend on which cells express the VDR and a better understanding of the signals that regulate VDR expression in immune cells.

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